Treatment of Class IV Lupus Nephritis with Mycophenolate Mofetil Monotherapy

被引：1

作者：

Nawata, Takashi ^{[1
]}

Kubo, Makoto ^{[1
]}

Fujii, Shohei ^{[1
]}

Shiragami, Kosaku ^{[1
]}

Ikegami, Tadayoshi ^{[1
]}

Kobayashi, Shigeki ^{[1
]}

Hisano, Satoshi ^{[2
]}

Yano, Masafumi ^{[1
]}

机构：

[1] Yamaguchi Univ, Dept Med & Clin Sci, Div Cardiol & Clin Immunol, Grad Sch Med, Yamaguchi, Japan

[2] Fukuoka Univ, Dept Pathol, Fac Med, Fukuoka, Japan

来源：

INTERNAL MEDICINE | 2018年 / 57卷 / 14期

基金：

日本学术振兴会;

关键词：

lupus nephritis; monotherapy; mycophenolate mofetil; steroid-free; HEART-FAILURE; CYCLOPHOSPHAMIDE; MECHANISMS; GLUCOCORTICOIDS; ERYTHEMATOSUS; INDUCTION;

D O I：

10.2169/internalmedicine.0304-17

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lupus nephritis (LN) occurs in up to 60% of systemic lupus erythematosus patients. Combination therapy involving a corticosteroid and cyclophosphamide or mycophenolate mofetil (MMF) has been a standard therapy for LN. However, clinicians generally prefer to minimize steroid use in LN treatment. We herein report the case of a Japanese man with LN whose severe chronic heart failure prevented us from using steroid therapy. Instead, his LN was successfully treated with MMF monotherapy. Based on our experience with this case, we suggest that MMF monotherapy may represent a feasible LN treatment option in patients who cannot tolerate steroid therapy.

引用

页码：2067 / 2070

页数：4

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