Transition-metal-free NaI-mediated reaction of aryl sulfonyl chloride with alkynes: Synthesis of (E)-β-iodovinyl sulfones

被引：6
|
作者：
Chen, Dan [1 ]
Lin, Li [1 ]
Peng, Xiaoyan [1 ]
Yu, Xinyi [1 ]
Yang, Zhonglie [1 ]
Liu, Yutong [1 ]
Zhang, Xiaobin [2 ]
Li, Jiahong [1 ]
Jiang, Hezhong [1 ]
机构：
[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China
[2] Sichuan Inst Atom Energy, Radiat Chem Dept, Irradiat Preservat Key Lab Sichuan Prov, Chengdu 610100, Peoples R China
来源：
TETRAHEDRON LETTERS | 2021年 / 75卷
基金：
中国国家自然科学基金;
关键词：
Alkynes; Arylsulfuryl chlorides; (E)-beta-iodovinyl sulfones; NaI-mediated; Transition-metal-free; BETA-KETO SULFONES; ONE-POT SYNTHESIS; VINYL SULFONES; EFFICIENT SYNTHESIS; CONJUGATE ADDITION; MICHAEL REACTIONS; ALKENES; ACCESS; IODOSULFONYLATION; CYCLOADDITION;
D O I：
10.1016/j.tetlet.2021.153203
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel protocol for synthesis of (E)-beta-Iodovinyl sulfones via NaI-mediated of aryl sulfonyl chloride with alkynes is described, featuring transition-metal-free condition, commercial available substrates, convenient operation, as well as good functional group compatibility. A wide variety of substrate application and good functional group tolerance is provided by this approach, giving multiple (E)-beta-Iodovinyl sulfones analogues with excellent yields (up to 98%, >4 g scale). (C) 2021 Elsevier Ltd. All rights reserved.
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页数：5
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