Transition-metal-free synthesis of aromatic amines via the reaction of benzynes with isocyanates

被引：8
|
作者：
Seo, Jeong Hoon [1 ]
Ko, Haye Min [1 ]
机构：
[1] Wonkwang Univ, Dept Bionano Chem, 460 Iksandae Ro, Iksan 54538, Jeonbuk, South Korea
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 07期
基金：
新加坡国家研究基金会;
关键词：
Aniline derivatives; Transition-metal-free; Benzynes; Isocyanates; Fluoride; N-ARYLATION; TERTIARY-AMINES; MILD CONDITIONS; ARYNES; INSERTION;
D O I：
10.1016/j.tetlet.2018.01.022
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unexpected reaction between benzynes and isocyanates to generate aromatic amines has been developed under transition-metal-free conditions. The in situ prepared anions formed through cleavage of the N-C bond in isocyanates, reacted with aryne precursors to afford various aniline derivatives in moderate to excellent yield and tolerated various substituents on the o-silyl aryl triflate and the isocyanate. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：671 / 674
页数：4
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