Transition-Metal-Free Heterobiaryl Synthesis via Aryne Coupling

被引：6

作者：

Saied, Tarak ^{[1
]}

Demangeat, Catherine ^{[1
]}

Panossian, Armen ^{[2
]}

Leroux, Frederic R. ^{[2
]}

Fort, Yves ^{[1
]}

Comoy, Corinne ^{[1
]}

机构：

[1] Univ Lorraine, CNRS, UMR7053, L2CM, BP 70239, F-54506 Vandoeuvre Les Nancy, France

[2] Univ Haute Alsace, Univ Strasbourg, CNRS, LIMA,ECPM,UMR 7042, F-67000 Strasbourg, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 31-32期

关键词：

Reaction mechanisms; Heterocyclic chemistry; Arynes; Salt effect; Ligand effects; DIALKYLAMIDE MIXED AGGREGATION; CHIRAL LITHIUM AMIDE; ENANTIOSELECTIVE ADDITION; ORGANOLITHIUM REAGENTS; AXIAL CHIRALITY; ATROPOSELECTIVE SYNTHESIS; HETEROCYCLIC CHEMISTRY; TERTIARY-AMINES; EFFICIENT TOOL; NMR;

D O I：

10.1002/ejoc.201900130

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We disclose, for the first time, an efficient route for the construction of various heterobiaryl backbones in fair to excellent yields using the Aryne coupling methodology. This study outlined the remarkable effect of external chelating ligands and salt additives on the heterocyclic partner reactivity in the aryne coupling reaction.

引用

页码：5275 / 5284

页数：10

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