Transition-Metal-Free Synthesis of Thiosulfonates through Radical Coupling Reaction

被引：14

作者：

Zhou, Guodong ^{[1
]}

Xu, Xu-Dong ^{[1
]}

Chen, Gan-Ping ^{[1
]}

Wei, Wen-Ting ^{[1
,2
]}

Guo, Zhiyong ^{[1
]}

机构：

[1] Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China

[2] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

SYNLETT | 2018年 / 29卷 / 15期

关键词：

transition-metal-free; radical coupling reaction; S-S bonds; thiosulfonates; OXIDATION; DISULFIDES; WATER; CYCLIZATION; SULFONYLHYDRAZIDES; SULFENYLATION; SULFONES; THIOLS; BONDS; ACIDS;

D O I：

10.1055/s-0037-1610649

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and practical transition-metal-free radical coupling reaction of sulfonyl hydrazides mediated by NIS/K(2)S(2)O(8)has been developed to afford a variety of biological activity thiosulfonates in moderate to excellent yields. Compared to a known approach for the synthesis of thiosulfonates from sulfonyl hydrazides, this strategy features high yields, mild reaction conditions, and broad substrate scope. The mechanistic studies revealed that the procedure undergoes via a radical cross-coupling process for the construction of S-S bonds.

引用

页码：2076 / 2080

页数：5

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