Transition-metal-free NaI-mediated reaction of aryl sulfonyl chloride with alkynes: Synthesis of (E)-β-iodovinyl sulfones

被引：6

作者：

Chen, Dan ^{[1
]}

Lin, Li ^{[1
]}

Peng, Xiaoyan ^{[1
]}

Yu, Xinyi ^{[1
]}

Yang, Zhonglie ^{[1
]}

Liu, Yutong ^{[1
]}

Zhang, Xiaobin ^{[2
]}

Li, Jiahong ^{[1
]}

Jiang, Hezhong ^{[1
]}

机构：

[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China

[2] Sichuan Inst Atom Energy, Radiat Chem Dept, Irradiat Preservat Key Lab Sichuan Prov, Chengdu 610100, Peoples R China

来源：

TETRAHEDRON LETTERS | 2021年 / 75卷

基金：

中国国家自然科学基金;

关键词：

Alkynes; Arylsulfuryl chlorides; (E)-beta-iodovinyl sulfones; NaI-mediated; Transition-metal-free; BETA-KETO SULFONES; ONE-POT SYNTHESIS; VINYL SULFONES; EFFICIENT SYNTHESIS; CONJUGATE ADDITION; MICHAEL REACTIONS; ALKENES; ACCESS; IODOSULFONYLATION; CYCLOADDITION;

D O I：

10.1016/j.tetlet.2021.153203

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel protocol for synthesis of (E)-beta-Iodovinyl sulfones via NaI-mediated of aryl sulfonyl chloride with alkynes is described, featuring transition-metal-free condition, commercial available substrates, convenient operation, as well as good functional group compatibility. A wide variety of substrate application and good functional group tolerance is provided by this approach, giving multiple (E)-beta-Iodovinyl sulfones analogues with excellent yields (up to 98%, >4 g scale). (C) 2021 Elsevier Ltd. All rights reserved.

引用

页数：5

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