Transition-Metal-Free Approach for the Synthesis of 4-Aryl-quinolines from Alkynes and Anilines

被引：54

作者：

Phanindrudu, Mandalaparthi ^{[1
,3
]}

Wakade, Sandip Balasaheb ^{[1
,3
]}

Tiwari, Dipak Kumar ^{[1
,3
]}

Likhar, Pravin R. ^{[2
,3
]}

Tiwari, Dharmendra Kumar ^{[1
,3
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Div Organ Synth & Proc Chem, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, CSIR, Inorgan & Phys Chem Div, Hyderabad 500007, India

[3] Acad Sci & Innovat Res AcSIR, New Delhi 110001, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 16期

关键词：

CATALYZED OXIDATIVE CYCLIZATION; HIGHLY REGIOSELECTIVE SYNTHESIS; 3-COMPONENT CASCADE ANNULATION; CANCER DRUG DISCOVERY; QUINOLINE DERIVATIVES; SUBSTITUTED QUINOLINES; PRIVILEGED SCAFFOLD; ACRIDONE ALKALOIDS; TERMINAL ALKYNES; ONE-POT;

D O I：

10.1021/acs.joc.8b01204

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and transition-metal-free approach for the synthesis of 4-arylquinolines from readily available anilines and alkynes in the presence of K2S2O8 and DMSO has been developed. A variety of alkynes and anilines having a diverse range of substitution patterns can undergo the one-pot cascade process successfully. Effectively, this method uses DMSO as one carbon source, thus providing a highly atom-economical and environmentally benign approach for the synthesis of 4-arylquinolines.

引用

页码：9137 / 9143

页数：7

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