Transition-Metal-Free Synthesis of Biarylmethanes from Aryl Iodides and Benzylic Ketones

被引：7

作者：

Drapeau, Martin Pichette ^{[1
,2
]}

Tlili, Anis ^{[2
,3
]}

Zaid, Yassir ^{[2
,4
]}

Toummini, Dounia ^{[2
,4
]}

Chahdi, Fouad Ouazzani ^{[4
]}

Sotiropoulos, Jean-Marc ^{[5
]}

Ollevier, Thierry ^{[1
]}

Taillefer, Marc ^{[2
]}

机构：

[1] Univ Laval, Dept Chim, Pavillon Alexandre Vachon,1045 Ave Med, Quebec City, PQ G1V 0A6, Canada

[2] ENSCM, Inst Charles Gerhardt Montpellier, 8 Rue Ecole Normale, F-34296 Montpellier, France

[3] Univ Lyon 1, Univ Lyon, CNRS, Inst Chem & Biochem ICBMS,UMR 5246, 43 Bd 11 Novembre 1918, F-69622 Villeurbanne, France

[4] Fac Sci & Tech, LCOA, Fes 30000, Morocco

[5] Univ Pau & Pays Adour, CNRS, Inst Sci Analyt & Phys Chim Environm & Mat, IPREM UMR 5254, Helioparc 2 Ave P Angot, F-64053 Pau, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2018年 / 24卷 / 66期

基金：

加拿大自然科学与工程研究理事会;

关键词：

biarylmethanes; C-C coupling; ketones; metal-free; superbase; FRIEDEL-CRAFTS REACTIONS; CROSS-COUPLING REACTION; C-H BENZYLATION; CATALYZED ARYLATION; ARYLBORONIC ACIDS; ENOLATE IONS; ALCOHOLS; DIARYLMETHANES; EFFICIENT; HALIDES;

D O I：

10.1002/chem.201804415

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An original metal-free procedure for the synthesis of biarylmethanes is disclosed herein. The reactions occur with high selectivity starting from aryl iodides and benzylic ketones in the presence of superbasic media (CsOH/DMSO). This procedure allows a straightforward access to a wide range of biarylmethane derivatives substituted with electron-withdrawing and -donating substituents.

引用

页码：17449 / 17453

页数：5

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