Mast cell infiltration is a favourable prognostic factor in diffuse large B-cell lymphoma

被引：60

作者：

Hedstrom, Gustaf ^{[1
]}

Berglund, Mattias

Molin, Daniel

Fischer, Marie

Nilsson, Gunnar

Thunberg, Ulf

Book, Majlis

Sundstrom, Christer

Rosenquist, Richard

Roos, Goran

Erlanson, Martin

Amini, Rose-Marie

Enblad, Gunilla

机构：

[1] Uppsala Univ, Rudbeck Lab, Dept Oncol, S-75145 Uppsala, Sweden

[2] Uppsala Univ, Dept Oncol Radiol & Clin Immunol, S-75145 Uppsala, Sweden

[3] Karolinska Inst, Dept Med, Stockholm, Sweden

[4] Univ Uppsala, Dept Genet & Pathol, S-75105 Uppsala, Sweden

[5] Uppsala Univ, Dept Biosci, Uppsala, Sweden

[6] Umea Univ, Dept Radiat Sci Oncol, Umea, Sweden

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 138卷 / 01期

关键词：

mast cells; non-Hodgkin lymphoma; prognostic factors;

D O I：

10.1111/j.1365-2141.2007.06612.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previous studies indicate that the inflammatory response in diffuse large B-cell lymphomas (DLBCL) is important for the clinical outcome. Mast cells are key regulators in this response; we investigated whether the number of tryptase-positive mast cells is correlated with clinical outcome. Patients with many mast cells had a significantly better event-free survival (EFS) compared to those with few mast cells (P < 0.03 in both germinal centre (GC) and non-GC DLBCL. This supports the idea that the infiltration of mast cells is a reflection of the host inflammatory response and is related to a favourable outcome.

引用

页码：68 / 71

页数：4

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