Mast cell infiltration is a favourable prognostic factor in diffuse large B-cell lymphoma

被引：60
|
作者：
Hedstrom, Gustaf [1 ]
Berglund, Mattias
Molin, Daniel
Fischer, Marie
Nilsson, Gunnar
Thunberg, Ulf
Book, Majlis
Sundstrom, Christer
Rosenquist, Richard
Roos, Goran
Erlanson, Martin
Amini, Rose-Marie
Enblad, Gunilla
机构：
[1] Uppsala Univ, Rudbeck Lab, Dept Oncol, S-75145 Uppsala, Sweden
[2] Uppsala Univ, Dept Oncol Radiol & Clin Immunol, S-75145 Uppsala, Sweden
[3] Karolinska Inst, Dept Med, Stockholm, Sweden
[4] Univ Uppsala, Dept Genet & Pathol, S-75105 Uppsala, Sweden
[5] Uppsala Univ, Dept Biosci, Uppsala, Sweden
[6] Umea Univ, Dept Radiat Sci Oncol, Umea, Sweden
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 138卷 / 01期
关键词：
mast cells; non-Hodgkin lymphoma; prognostic factors;
D O I：
10.1111/j.1365-2141.2007.06612.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Previous studies indicate that the inflammatory response in diffuse large B-cell lymphomas (DLBCL) is important for the clinical outcome. Mast cells are key regulators in this response; we investigated whether the number of tryptase-positive mast cells is correlated with clinical outcome. Patients with many mast cells had a significantly better event-free survival (EFS) compared to those with few mast cells (P < 0.03 in both germinal centre (GC) and non-GC DLBCL. This supports the idea that the infiltration of mast cells is a reflection of the host inflammatory response and is related to a favourable outcome.
引用
收藏
页码：68 / 71
页数：4
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