17β-estradiol regulates nNOs and eNOS activity in the hippocampus

被引：59

作者：

Grohé, C

Kann, S

Fink, L

Djoufack, PC

Paehr, M

van Eickels, M

Vetter, H

Meyer, R

Fink, KB

机构：

[1] Univ Bonn, Sch Med, Dept Pharmacol, D-53113 Bonn, Germany

[2] Univ Bonn, Sch Med, Med Univ Policlin, D-53113 Bonn, Germany

[3] Univ Bonn, Sch Med, Inst Physiol 2, D-53113 Bonn, Germany

[4] Univ Giessen, Inst Pathol, D-35392 Giessen, Germany

来源：

NEUROREPORT | 2004年 / 15卷 / 01期

关键词：

estrogen; endothelial NO synthase; hippocampus; neuronal NO synthase;

D O I：

10.1097/01.wnr.0000103270.91211.a1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Estrogen treatment in symptomatic postmenopausal women appears to improve cognitive performance including memory, an effect which may involve enhanced nitric oxide formation in hippocampal neurons. To study whether 17beta-estradiol (E2) affects NO synthase activity in the hippocampus, we investigated the influence of E2 on hippocampal NO synthase expression and activity in female rats. Ovariectomy, which significantly decreased E2 serum levels, reduced neuronal (nNOS) and endothelial NO synthase (eNOS) expression and Ca2+-dependent NOS activity. E2 substitution reversed these effects. It is concluded that E2 increases nNOS and eNOS expression and activity in female hippocampus and thus improves hippocampal function.

引用

页码：89 / 93

页数：5

共 50 条

[41] Inhibitory effect of 17β-estradiol to neuronal apoptosis in gerbil hippocampus induce by ischemia
Fujita, K
Yamauchi, M
Kato, T
Shibayama, K
Ando, M
Yoshimoto, N
Nagata, Y
Miyachi, E
[J]. JOURNAL OF NEUROCHEMISTRY, 2003, 87 : 129 - 129
[42] The effects of 17β-estradiol on ischemia-induced neuronal damage in the gerbil hippocampus
Chen, J
Adachi, N
Liu, K
Arai, T
[J]. NEUROSCIENCE, 1998, 87 (04) : 817 - 822
[43] Effects of 17β-estradiol replacement on the apoptotic effects caused by ovariectomy in the rat hippocampus
Sales, Sayuri
Ureshino, Rodrigo Portes
dos Santos Pereira, Renato Tavares
Amaral Luna, Milene Schmidt
de Oliveira, Marcelo Pires
Yamanouye, Norma
Godinho, Rosely Oliveira
Smaili, Soraya Soubhi
Porto, Catarina Segreti
Francis Abdalla, Fernando Mauricio
[J]. LIFE SCIENCES, 2010, 86 (21-22) : 832 - 838
[44] Pathway of 17β-estradiol degradation by Nitrosomonas europaea and reduction in 17β-estradiol-derived estrogenic activity
Nakai, Satoshi
Yamamura, Anri
Tanaka, Shou
Shi, Jianghong
Nishikawa, Megumi
Nakashimada, Yutaka
Hosomi, Masaaki
[J]. ENVIRONMENTAL CHEMISTRY LETTERS, 2011, 9 (01) : 1 - 6
[45] Pathway of 17β-estradiol degradation by Nitrosomonas europaea and reduction in 17β-estradiol-derived estrogenic activity
Satoshi Nakai
Anri Yamamura
Shou Tanaka
Jianghong Shi
Megumi Nishikawa
Yutaka Nakashimada
Masaaki Hosomi
[J]. Environmental Chemistry Letters, 2011, 9 : 1 - 6
[46] 17β-estradiol improves the eNOS dysfunction in hyperglycemia:: implication for anti-atherosclerotic effect of estrogen
Miyazaki, A
Hayashi, T
Matsui-Hirai, H
Fukatsu, A
Juliet, PAR
Funami, J
Iguchi, A
[J]. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2004, 11 (01): : 124 - 124
[47] Cerebral arteriolar regulation of eNOS and nNOS at reduced oxygen tension
Bauser, Holly Diane
Bohlen, Harold Glenn
[J]. FASEB JOURNAL, 2007, 21 (05): : A482 - A482
[48] Expression and regulation of NOSIP, an interactor of eNOS and nNOS in the nervous system
Dreyer, J
Schleicher, M
Oess, S
Müller-Esterl, W
Kuner, R
[J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2003, 367 : R41 - R41
[49] EVIDENCE THAT ADENOSINE REGULATES INTERICTAL SPIKE ACTIVITY IN THE HIPPOCAMPUS
FREDHOLM, BB
DUNWIDDIE, T
HOFFER, B
LINDSTROM, K
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1981, 112 (02): : A8 - A8
[50] An nNOS-unrelated activity of nNOS inhibitors
Matsumura, Nobuko
Utsumi, Kazue
Nakaki, Toshio
[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 106 : 228P - 228P

← 1 2 3 4 5 →