17β-estradiol regulates nNOs and eNOS activity in the hippocampus

被引：59

作者：

Grohé, C

Kann, S

Fink, L

Djoufack, PC

Paehr, M

van Eickels, M

Vetter, H

Meyer, R

Fink, KB

机构：

[1] Univ Bonn, Sch Med, Dept Pharmacol, D-53113 Bonn, Germany

[2] Univ Bonn, Sch Med, Med Univ Policlin, D-53113 Bonn, Germany

[3] Univ Bonn, Sch Med, Inst Physiol 2, D-53113 Bonn, Germany

[4] Univ Giessen, Inst Pathol, D-35392 Giessen, Germany

来源：

NEUROREPORT | 2004年 / 15卷 / 01期

关键词：

estrogen; endothelial NO synthase; hippocampus; neuronal NO synthase;

D O I：

10.1097/01.wnr.0000103270.91211.a1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Estrogen treatment in symptomatic postmenopausal women appears to improve cognitive performance including memory, an effect which may involve enhanced nitric oxide formation in hippocampal neurons. To study whether 17beta-estradiol (E2) affects NO synthase activity in the hippocampus, we investigated the influence of E2 on hippocampal NO synthase expression and activity in female rats. Ovariectomy, which significantly decreased E2 serum levels, reduced neuronal (nNOS) and endothelial NO synthase (eNOS) expression and Ca2+-dependent NOS activity. E2 substitution reversed these effects. It is concluded that E2 increases nNOS and eNOS expression and activity in female hippocampus and thus improves hippocampal function.

引用

页码：89 / 93

页数：5

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