Research progress on the regulatory role of microRNAs in spinal cord injury

被引：16
|
作者：
Guo, Xu-Dong [1 ,2 ]
He, Xue-Gang [1 ,2 ]
Yang, Feng-Guang [1 ,2 ]
Liu, Ming-Qiang [1 ,2 ]
Wang, Yi-Dian [1 ,2 ]
Zhu, Da-Xue [1 ,2 ]
Zhang, Guang-Zhi [1 ,2 ]
Ma, Zhan-Jun [1 ,2 ]
Kang, Xue-Wen [1 ,2 ,3 ]
机构：
[1] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Hosp 2, Dept Orthoped, Lanzhou 730000, Gansu, Peoples R China
[3] Int Cooperat Base Gansu Prov Pain Res Spinal Diso, Lanzhou 730000, Gansu, Peoples R China
来源：
REGENERATIVE MEDICINE | 2021年 / 16卷 / 05期
关键词：
exosome; lncRNA– miRNA network; microRNAs; spinal cord injury; ISCHEMIA-REPERFUSION INJURY; FUNCTIONAL RECOVERY; STEM-CELLS; EXTRACELLULAR VESICLES; INFLAMMATORY RESPONSE; NONCODING RNAS; PC-12; CELLS; MICROGLIA; ACTIVATION; APOPTOSIS;
D O I：
10.2217/rme-2020-0125
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Spinal cord injury (SCI) is a severe CNS injury that results in abnormalities in, or loss of, motor, sensory and autonomic nervous function. miRNAs belong to a new class of noncoding RNA that regulates the production of proteins and biological function of cells by silencing translation or interfering with the expression of target mRNAs. Following SCI, miRNAs related to oxidative stress, inflammation, autophagy, apoptosis and many other secondary injuries are differentially expressed, and these miRNAs play an important role in the progression of secondary injuries after SCI. The purpose of this review is to elucidate the differential expression and functional roles of miRNAs after SCI, thus providing references for further research on miRNAs in SCI.
引用
收藏
页码：465 / 476
页数：12
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