Research progress on the regulatory role of microRNAs in spinal cord injury

被引：16
|
作者：
Guo, Xu-Dong [1 ,2 ]
He, Xue-Gang [1 ,2 ]
Yang, Feng-Guang [1 ,2 ]
Liu, Ming-Qiang [1 ,2 ]
Wang, Yi-Dian [1 ,2 ]
Zhu, Da-Xue [1 ,2 ]
Zhang, Guang-Zhi [1 ,2 ]
Ma, Zhan-Jun [1 ,2 ]
Kang, Xue-Wen [1 ,2 ,3 ]
机构：
[1] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Hosp 2, Dept Orthoped, Lanzhou 730000, Gansu, Peoples R China
[3] Int Cooperat Base Gansu Prov Pain Res Spinal Diso, Lanzhou 730000, Gansu, Peoples R China
来源：
REGENERATIVE MEDICINE | 2021年 / 16卷 / 05期
关键词：
exosome; lncRNA– miRNA network; microRNAs; spinal cord injury; ISCHEMIA-REPERFUSION INJURY; FUNCTIONAL RECOVERY; STEM-CELLS; EXTRACELLULAR VESICLES; INFLAMMATORY RESPONSE; NONCODING RNAS; PC-12; CELLS; MICROGLIA; ACTIVATION; APOPTOSIS;
D O I：
10.2217/rme-2020-0125
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Spinal cord injury (SCI) is a severe CNS injury that results in abnormalities in, or loss of, motor, sensory and autonomic nervous function. miRNAs belong to a new class of noncoding RNA that regulates the production of proteins and biological function of cells by silencing translation or interfering with the expression of target mRNAs. Following SCI, miRNAs related to oxidative stress, inflammation, autophagy, apoptosis and many other secondary injuries are differentially expressed, and these miRNAs play an important role in the progression of secondary injuries after SCI. The purpose of this review is to elucidate the differential expression and functional roles of miRNAs after SCI, thus providing references for further research on miRNAs in SCI.
引用
收藏
页码：465 / 476
页数：12
相关论文
共 50 条
  • [21] Research progress on long non-coding RNAs for spinal cord injury
    Musen Zhong
    Guangya Fan
    Zhongcheng An
    Chen Chen
    Liqiang Dong
    [J]. Journal of Orthopaedic Surgery and Research, 18
  • [22] Research Progress of Antioxidants in Oxidative Stress Therapy after Spinal Cord Injury
    Can Zhang
    Tianyu Zhai
    Jinghui Zhu
    Dongmin Wei
    Shuting Ren
    Yanling Yang
    Feng Gao
    Lin Zhao
    [J]. Neurochemical Research, 2023, 48 : 3473 - 3484
  • [23] Research progress on long non-coding RNAs for spinal cord injury
    Zhong, Musen
    Fan, Guangya
    An, Zhongcheng
    Chen, Chen
    Dong, Liqiang
    [J]. JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, 2023, 18 (01)
  • [24] The Latest View on the Mechanism of Ferroptosis and Its Research Progress in Spinal Cord Injury
    Chen, Yixin
    Liu, Suixin
    Li, Jianjun
    Li, Zhe
    Quan, Jing
    Liu, Xinzhou
    Tang, Yinbo
    Liu, Bin
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020, 2020
  • [25] Research Progress of Long Non-coding RNAs in Spinal Cord Injury
    Cai, Zongyan
    Han, Xue
    Li, Ruizhe
    Yu, Tianci
    Chen, Lei
    Wu, XueXue
    Jin, Jiaxin
    [J]. NEUROCHEMICAL RESEARCH, 2023, 48 (01) : 1 - 12
  • [26] Research progress in use of traditional Chinese medicine for treatment of spinal cord injury
    Lu, Yubao
    Yang, Jingjing
    Wang, Xuexi
    Ma, Zhanjun
    Li, Sheng
    Liu, Zhaoyang
    Fan, Xuegong
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2020, 127
  • [27] Research Progress of Antioxidants in Oxidative Stress Therapy after Spinal Cord Injury
    Zhang, Can
    Zhai, Tianyu
    Zhu, Jinghui
    Wei, Dongmin
    Ren, Shuting
    Yang, Yanling
    Gao, Feng
    Zhao, Lin
    [J]. NEUROCHEMICAL RESEARCH, 2023, 48 (12) : 3473 - 3484
  • [28] Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury
    Pang, Qi-Ming
    Chen, Si-Yu
    Fu, Sheng-Ping
    Zhou, Hui
    Zhang, Qian
    Ao, Jun
    Luo, Xiao-Ping
    Zhang, Tao
    [J]. JOURNAL OF INFLAMMATION RESEARCH, 2022, 15 : 573 - 593
  • [29] Angiogenesis in Spinal Cord Injury: Progress and Treatment
    Tsivelekas, Konstantinos
    Evangelopoulos, Dimitrios Stergios
    Pallis, Dimitrios
    Benetos, Ioannis S.
    Papadakis, Stamatios A.
    Vlamis, John
    Pneumaticos, Spyros G.
    [J]. CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (05)
  • [30] Regulatory effects of internn ttent noxious St nnulation on spinal cord injury-sensitive microRNAs and their presumptive targets following spinal cord contusion
    Strickland, Eric R.
    Woller, Sarah A.
    Garraway, Sandra M.
    Hook, Michelle A.
    Grau, James W.
    Miranda, Rajesh C.
    [J]. FRONTIERS IN NEURAL CIRCUITS, 2014, 8
12345