An Efficient Method for Synthesis of Some Novel Spirooxindole-4H-Pyran Derivatives

Oxindoles and spirooxindoles as poly-functionalized heterocycles are important synthetic targets because of their biological activity and applications to pharmaceutical guide discovery. The spirooxindole structure is usually found in a variety of complex alkaloids and many compounds that possess biological activity. In this study, we have proposed an easy and efficient access to spirooxindole from N-alkylated isatin derivatives, an activated methylene and 4-hydroxycumarin to get such compounds powerfully and suitably. Here we synthesized 18 new derivatives (4a-4r) of spirooxindoles by multicomponent reaction method. Chemical structures of all products were confirmed by IR, (HNMR)-H-1, (CNMR)-C-13, and Mass Spectroscopy. The reaction conditions were also optimized in the point of different kinds of catalysts, temperature, and solvents.