Efficient and mild cyclization procedures for the synthesis of novel 2-amino-4H-pyran derivatives with potential antitumor activity

被引：38

作者：

Wang, Dao-Cai ^{[1
]}

Xie, Yong-Mei ^{[2
]}

Fan, Chen ^{[2
]}

Yao, Shun ^{[1
]}

Song, Hang ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem Engn, Dept Pharmaceut & Biol Engn, Chengdu 610065, Peoples R China

[2] Sichuan Univ, West China Med Sch, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2014年 / 25卷 / 07期

关键词：

Synthesis; 2-Amino-4H-pyran derivatives; Multicomponent; Anticancer; ZANTHOXYLUM SIMULANS; QUINOLINE ALKALOIDS; MELICOPE-DENHAMII; CONSTITUENTS;

D O I：

10.1016/j.cclet.2014.04.026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel 2-amino-4H-pyran derivatives have been synthesized via a three-component reaction of a, p-unsaturated ketone derivatives, malononitrile, aldehydes in excellent yields, using DBU as a catalyst and ethanol as a cheap, safe, and environmentally benign solvent under mild conditions. Their antitumor activity was evaluated in three human tumor cell lines, including human colon cancer (HCT116), human cervical cancer (Hela), and non-small cell lung cancer (H1975). (C) 2014 Hang Song. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1011 / 1013

页数：3

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