Synthesis and molecular structure of spirocyclic 2-oxindole derivatives of 2-amino-4H-pyran condensed with the pyrazolic nucleus

被引：107

作者：

Redkin, Ruslan Gr. ^{[1
]}

Shemchuk, Leonid A. ^{[1
]}

Chernykh, Valentine P. ^{[1
]}

Shishkin, Oleg V. ^{[2
]}

Shishkina, Svetlana V. ^{[2
]}

机构：

[1] Natl Pharmaceut Univ, UA-61001 Kahrkiv, Ukraine

[2] Natl Acad Sci Ukraine, STC Inst Single Crystals, UA-61001 Kahrkiv, Ukraine

来源：

TETRAHEDRON | 2007年 / 63卷 / 46期

关键词：

3-spiro-2-oxindoles; pyrano[2,3-c]pyrazol; methylene active nitriles; Michael reaction; X-ray diffraction analysis;

D O I：

10.1016/j.tet.2007.08.050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4,3'-Spiro[(6-amino-5-R-3-methyl-2H,4H-pyrano[2,3-c]pyrazolo)-2'-oxindoles] were synthesized based on the three-component condensation of isatins with 3-methyl-pyrazolone-5 and respective methylene active nitriles in the presence of basic catalysts. The molecular structure of the resulting compounds was proved unambiguously by X-ray diffraction. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：11444 / 11450

页数：7

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