Oxidation of feric-cytochrome c by N,N′-bis(2-hydroperoxy-2-methoxyethyl)-1,4,5,8-naphthalene tetracarboxylic diimide, NP III -: Site specific modification of cytochrome c

被引：0

作者：

Matsugo, S

Yasui, F

Konishi, T

机构：

[1] Toyama Univ, Fac Engn, Dept Chem & Biochem Engn, Toyama 930, Japan

[2] Niigata Coll Pharm, Niigata 95021, Japan

来源：

BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL | 1997年 / 42卷 / 06期

关键词：

hydroxyl radical; cytochrome c; specific protein damage; photo-fenton reagent; Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectroscopy (MALDI-TOF);

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When the synthetic hydroxyl radical generator, N,N'-bis (2-Hydroperoxy-2-methoxyethyl)-1,4,5,8-naphthalene-tetracarboxylic diimide, NP III, was photoirradiated in the presence of ferric-cytochrome c (Fe3+), the fragmentation peak corresponding to the specific oxidative modification at the histidine site of cytochrome c was observed in the Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectroscopy (MALDI-TOF) measurement.. Without photoirradiation, no such protein oxidation was observed in the experimental conditions employed. This result suggests the possible usage of NP-III as an oxidative protein-modifying reagent.

引用

页码：1081 / 1087

页数：7

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