Oxidation of feric-cytochrome c by N,N′-bis(2-hydroperoxy-2-methoxyethyl)-1,4,5,8-naphthalene tetracarboxylic diimide, NP III -: Site specific modification of cytochrome c

被引：0
|
作者：
Matsugo, S
Yasui, F
Konishi, T
机构：
[1] Toyama Univ, Fac Engn, Dept Chem & Biochem Engn, Toyama 930, Japan
[2] Niigata Coll Pharm, Niigata 95021, Japan
来源：
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL | 1997年 / 42卷 / 06期
关键词：
hydroxyl radical; cytochrome c; specific protein damage; photo-fenton reagent; Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectroscopy (MALDI-TOF);
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
When the synthetic hydroxyl radical generator, N,N'-bis (2-Hydroperoxy-2-methoxyethyl)-1,4,5,8-naphthalene-tetracarboxylic diimide, NP III, was photoirradiated in the presence of ferric-cytochrome c (Fe3+), the fragmentation peak corresponding to the specific oxidative modification at the histidine site of cytochrome c was observed in the Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectroscopy (MALDI-TOF) measurement.. Without photoirradiation, no such protein oxidation was observed in the experimental conditions employed. This result suggests the possible usage of NP-III as an oxidative protein-modifying reagent.
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收藏
页码：1081 / 1087
页数：7
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