A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss

被引：19

作者：

Ueberfuhr, Margarete A. ^{[1
]}

Fehlberg, Hannah ^{[2
]}

Goodman, Shawn S. ^{[3
]}

Withnell, Robert H. ^{[4
]}

机构：

[1] Univ Munich, Grad Sch Syst Neurosci, Munich, Germany

[2] Univ Minnesota, Med Ctr, Audiol & Aural Rehabil, Minneapolis, MN 55455 USA

[3] Univ Iowa, Dept Commun Sci & Disorders, Iowa City, IA 52242 USA

[4] Indiana Univ, Dept Speech & Hearing Sci, Bloomington, IN 47405 USA

来源：

HEARING RESEARCH | 2016年 / 332卷

关键词：

Otoacoustic emission; Presbycusis; Model; DISTORTION-PRODUCT; OTOACOUSTIC EMISSIONS; AUDIOMETRIC SHAPE; COCHLEAR; MODEL; PRESBYCUSIS; DEGENERATION; ADDITIVITY; REDUCTION; PRESTIN;

D O I：

10.1016/j.heares.2015.11.006

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Distortion product otoacoustic emissions (DPOAEs) were used to assess outer hair cell (OHC) integrity in human ears with age-related hearing loss. Sound pressure measurements were made in the ear canal over the stimulus range 40-90 dB SPL (L-2), with L-1 = 0A5*L-2 + 44 with F-2 = 2 and 3 or 4 kHz. Model generated DPOAE I/O functions were fit to DPOAE data to quantify the contribution of loss of nonlinearity (OHC loss) to the hearing loss. Results suggest OHC loss as a contributing cause of age-related hearing, regardless of audiogram configuration. It seems likely that OHC and stria] pathology co-exist in ears with AHL. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：137 / 150

页数：14

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