A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss

被引：19
|
作者：
Ueberfuhr, Margarete A. [1 ]
Fehlberg, Hannah [2 ]
Goodman, Shawn S. [3 ]
Withnell, Robert H. [4 ]
机构：
[1] Univ Munich, Grad Sch Syst Neurosci, Munich, Germany
[2] Univ Minnesota, Med Ctr, Audiol & Aural Rehabil, Minneapolis, MN 55455 USA
[3] Univ Iowa, Dept Commun Sci & Disorders, Iowa City, IA 52242 USA
[4] Indiana Univ, Dept Speech & Hearing Sci, Bloomington, IN 47405 USA
来源：
HEARING RESEARCH | 2016年 / 332卷
关键词：
Otoacoustic emission; Presbycusis; Model; DISTORTION-PRODUCT; OTOACOUSTIC EMISSIONS; AUDIOMETRIC SHAPE; COCHLEAR; MODEL; PRESBYCUSIS; DEGENERATION; ADDITIVITY; REDUCTION; PRESTIN;
D O I：
10.1016/j.heares.2015.11.006
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
Distortion product otoacoustic emissions (DPOAEs) were used to assess outer hair cell (OHC) integrity in human ears with age-related hearing loss. Sound pressure measurements were made in the ear canal over the stimulus range 40-90 dB SPL (L-2), with L-1 = 0A5*L-2 + 44 with F-2 = 2 and 3 or 4 kHz. Model generated DPOAE I/O functions were fit to DPOAE data to quantify the contribution of loss of nonlinearity (OHC loss) to the hearing loss. Results suggest OHC loss as a contributing cause of age-related hearing, regardless of audiogram configuration. It seems likely that OHC and stria] pathology co-exist in ears with AHL. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：137 / 150
页数：14
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