Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane

被引：1
|
作者：
Fontana, Gabriele A. [1 ]
Rass, Ulrich [2 ]
机构：
[1] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Zurich, Switzerland
[2] Univ Sussex, Sch Life Sci, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2019年 / 6卷 / 06期
关键词：
NHEJ; HR; chromosome stability; protein palmitoylation; DHHC palmitoyl transferases; Pfa4; TELOMERES;
D O I：
10.1080/23723556.2019.1648025
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting factor 1 (Rif1) as a mechanism providing spatial control over DSB repair pathway choice.
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
    Fontana, Gabriele A.
    Hess, Daniel
    Reinert, Julia K.
    Mattarocci, Stefano
    Falquet, Benoit
    Klein, Dominique
    Shore, David
    Thoma, Nicolas H.
    Rass, Ulrich
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [2] Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
    Gabriele A. Fontana
    Daniel Hess
    Julia K. Reinert
    Stefano Mattarocci
    Benoît Falquet
    Dominique Klein
    David Shore
    Nicolas H. Thomä
    Ulrich Rass
    Nature Communications, 10
  • [3] RIF1 Links Replication Timing with Fork Reactivation and DNA Double-Strand Break Repair
    Blasiak, Janusz
    Szczepanska, Joanna
    Sobczuk, Anna
    Fila, Michal
    Pawlowska, Elzbieta
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (21)
  • [4] DNA double-strand break repair
    Featherstone, C
    Jackson, SP
    CURRENT BIOLOGY, 1999, 9 (20) : R759 - R761
  • [5] Nuclear organization of DNA double-strand break repair.
    Lisby, M
    Barlow, J
    Mortensen, U
    Rothstein, R
    YEAST, 2003, 20 : S91 - S91
  • [6] RIF1 in DNA Break Repair Pathway Choice
    Daley, James M.
    Sung, Patrick
    MOLECULAR CELL, 2013, 49 (05) : 840 - 841
  • [7] DNA double-strand break repair and development
    Phillips, E. R.
    McKinnon, P. J.
    ONCOGENE, 2007, 26 (56) : 7799 - 7808
  • [8] DksA and DNA double-strand break repair
    Myka, Kamila K.
    Gottesman, Max E.
    CURRENT GENETICS, 2019, 65 (06) : 1297 - 1300
  • [9] DNA double-strand break repair and development
    E R Phillips
    P J McKinnon
    Oncogene, 2007, 26 : 7799 - 7808
  • [10] DksA and DNA double-strand break repair
    Kamila K. Myka
    Max E. Gottesman
    Current Genetics, 2019, 65 : 1297 - 1300
12345