Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane

被引：1
|
作者：
Fontana, Gabriele A. [1 ]
Rass, Ulrich [2 ]
机构：
[1] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Zurich, Switzerland
[2] Univ Sussex, Sch Life Sci, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2019年 / 6卷 / 06期
关键词：
NHEJ; HR; chromosome stability; protein palmitoylation; DHHC palmitoyl transferases; Pfa4; TELOMERES;
D O I：
10.1080/23723556.2019.1648025
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DNA double-strand breaks (DSBs) disrupt the structural integrity of chromosomes. Proper DSB repair pathway choice is critical to avoid the type of gross chromosomal rearrangements that characterize cancer cells. Recent findings reveal S-fatty acylation and membrane anchorage of Rap1-interacting factor 1 (Rif1) as a mechanism providing spatial control over DSB repair pathway choice.
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页数：3
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