Novel Aryl and Heteroaryl Acyl Sulfamide Synthesis via Microwave-Assisted Palladium-Catalyzed Carbonylation

被引：16
|
作者：
Roberts, Bryan [1 ]
Liptrot, David [1 ]
Alcaraz, Lilian [1 ]
机构：
[1] AstraZeneca R&D Charnwood, Dept Med Chem, Loughborough LE11 5RH, Leics, England
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 06期
关键词：
CARBON-MONOXIDE; ATMOSPHERIC-PRESSURE; N-ARYL; AGENTS; AMINOCARBONYLATION;
D O I：
10.1021/ol100083w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel, simple synthesis of aryl and heteroaryl acyl sulfamides has been developed via palladium-catalyzed carbonylation of aryl or heteroaryl halides in the presence of sulfamide nucleophiles. A range of reactions Illustrating the wide scope of this reaction was carried out under microwave Irradiation In a vessel equipped with a gas inlet adapter and proceeded in good to excellent yields.
引用
收藏
页码：1264 / 1267
页数：4
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