New Synthesis of Aryl and Heteroaryl N-Acylureas via Microwave-Assisted Palladium-Catalysed Carbonylation

被引：30

作者：

Liptrot, David ^{[1
]}

Alcaraz, Lilian ^{[1
]}

Roberts, Bryan ^{[1
]}

机构：

[1] AstraZeneca R&D Charnwood, Dept Chem, Loughborough LE11 5RH, Leics, England

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 13期

关键词：

N-acylureas; carbonylation; homogenous catalysis; microwave heating; palladium; ureas; CARBON-MONOXIDE SOURCE; PROMOTED AMINOCARBONYLATION; ATMOSPHERIC-PRESSURE; MO(CO)(6); CHLORIDES; BROMIDES; IODIDES; ESTERS;

D O I：

10.1002/adsc.201000395

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new, practical synthesis of aryl and heteroaryl N-acylureas has been developed via palladium-catalysed carbonylation of aryl or heteroaryl halides in the presence of urea nucleophiles. A range of reactions illustrating the wide scope of this reaction was carried out under microwave irradiation, using either carbon monoxide gas in a vessel equipped with a gas inlet adapter, or molybdenum hexacarbonyl as the carbon monoxide source in standard microwave vials. The reactions proceeded in good to excellent yields. To illustrate the usefulness of this method a one-step synthesis of the important insecticide diflubenzuron is reported.

引用

页码：2183 / 2188

页数：6

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