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New Synthesis of Aryl and Heteroaryl N-Acylureas via Microwave-Assisted Palladium-Catalysed Carbonylation
被引:30
|作者:
Liptrot, David
[1
]
Alcaraz, Lilian
[1
]
Roberts, Bryan
[1
]
机构:
[1] AstraZeneca R&D Charnwood, Dept Chem, Loughborough LE11 5RH, Leics, England
关键词:
N-acylureas;
carbonylation;
homogenous catalysis;
microwave heating;
palladium;
ureas;
CARBON-MONOXIDE SOURCE;
PROMOTED AMINOCARBONYLATION;
ATMOSPHERIC-PRESSURE;
MO(CO)(6);
CHLORIDES;
BROMIDES;
IODIDES;
ESTERS;
D O I:
10.1002/adsc.201000395
中图分类号:
O69 [应用化学];
学科分类号:
081704 ;
摘要:
A new, practical synthesis of aryl and heteroaryl N-acylureas has been developed via palladium-catalysed carbonylation of aryl or heteroaryl halides in the presence of urea nucleophiles. A range of reactions illustrating the wide scope of this reaction was carried out under microwave irradiation, using either carbon monoxide gas in a vessel equipped with a gas inlet adapter, or molybdenum hexacarbonyl as the carbon monoxide source in standard microwave vials. The reactions proceeded in good to excellent yields. To illustrate the usefulness of this method a one-step synthesis of the important insecticide diflubenzuron is reported.
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页码:2183 / 2188
页数:6
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