Palladium-Catalyzed Synthesis of Aryl and Heteroaryl Difluoromethylated Phosphonates

被引：10

作者：

Ivanova, Maria V. ^{[1
]}

Besset, Tatiana ^{[1
]}

Pannecoucke, Xavier ^{[1
]}

Poisson, Thomas ^{[1
,2
]}

机构：

[1] Normandie Univ, INSA Rouen, UNIROUEN, CNRS,COBRA,UMR 6014, F-76000 Rouen, France

[2] Inst Univ France, 103 Blvd St Michel, F-75005 Paris, France

来源：

SYNTHESIS-STUTTGART | 2018年 / 50卷 / 04期

关键词：

fluorine; phosphate mimic; synthetic method; palladium; copper; PHOSPHATASE 1B INHIBITORS; MEDICINAL CHEMISTRY; FUNCTIONAL-GROUPS; RECENT PROGRESS; BORONIC ACIDS; FLUORINE; ALKENES; TRIFLUOROMETHYLATION; DISCOVERY; DIFLUORO;

D O I：

10.1055/s-0036-1589140

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the palladium-catalyzed introduction of the difluoromethylposphonate unit onto aryl and heteroaryl iodides under mild conditions. Using the CuCF2PO(OEt)(2) species generated in situ, the method allows the functionalization of various otherwise reluctant substrates. In addition, this reaction permits the formation of CF2PO(OEt)(2)-containing heterocycles, an important class of compounds. This process broadens the current toolbox of methods available to construct CF2PO(OEt)(2)-containing molecules.

引用

页码：778 / 784

页数：7

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