Arginine methyltransferase inhibitor 1 exhibits antitumor effects against cervical cancer in vitro and in vivo

被引：7

作者：

Dong, Shu-Hong ^{[1
]}

Wang, Xing ^{[2
]}

Tian, San-Chun ^{[1
]}

Ma, Neng-Qian ^{[2
]}

Zhang, Xin-Yang ^{[2
]}

Liu, Yapeng ^{[1
]}

Zhang, Bao-Lai ^{[1
]}

Wu, Yong-Jie ^{[1
]}

机构：

[1] Lanzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Lanzhou, Gansu, Peoples R China

[2] Lanzhou Univ, Sch Med, Hosp 2, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou, Gansu, Peoples R China

来源：

PHARMAZIE | 2018年 / 73卷 / 05期

关键词：

CELL LUNG-CANCER; TUMOR-SUPPRESSOR; PROTEIN; METHYLATION; PRMT5; GROWTH; EIF4E; LYMPHOMA;

D O I：

10.1691/ph.2018.8365

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Protein arginine methyltransferase 5 (PRMT5), a type II PRMT, is highly expressed in several types of tumors including cervical cancer. Arginine methyltransferase inhibitor 1 (AMI-1) inhibits solid tumors by targeting PRMT5. However, the effect of AMI-1 on cervical cancer is still unknown. In this study, we provided the first evidence that AMI-1 reduced cervical cancer cell proliferation, colony formation and promoted cell apoptosis in vitro. Suppression of tumorigenicity was also confirmed in vivo. Mechanistic studies revealed that AMI-1 significantly reduced PRMT5 level in cells and mice xenografts model of cervical cancer. These results suggest that AMI-1 inhibits cervical cancer by type II PRMT5.

引用

页码：269 / 273

页数：5

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