Arginine methyltransferase inhibitor 1 exhibits antitumor effects against cervical cancer in vitro and in vivo

被引：7
|
作者：
Dong, Shu-Hong [1 ]
Wang, Xing [2 ]
Tian, San-Chun [1 ]
Ma, Neng-Qian [2 ]
Zhang, Xin-Yang [2 ]
Liu, Yapeng [1 ]
Zhang, Bao-Lai [1 ]
Wu, Yong-Jie [1 ]
机构：
[1] Lanzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Lanzhou, Gansu, Peoples R China
[2] Lanzhou Univ, Sch Med, Hosp 2, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou, Gansu, Peoples R China
来源：
PHARMAZIE | 2018年 / 73卷 / 05期
关键词：
CELL LUNG-CANCER; TUMOR-SUPPRESSOR; PROTEIN; METHYLATION; PRMT5; GROWTH; EIF4E; LYMPHOMA;
D O I：
10.1691/ph.2018.8365
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Protein arginine methyltransferase 5 (PRMT5), a type II PRMT, is highly expressed in several types of tumors including cervical cancer. Arginine methyltransferase inhibitor 1 (AMI-1) inhibits solid tumors by targeting PRMT5. However, the effect of AMI-1 on cervical cancer is still unknown. In this study, we provided the first evidence that AMI-1 reduced cervical cancer cell proliferation, colony formation and promoted cell apoptosis in vitro. Suppression of tumorigenicity was also confirmed in vivo. Mechanistic studies revealed that AMI-1 significantly reduced PRMT5 level in cells and mice xenografts model of cervical cancer. These results suggest that AMI-1 inhibits cervical cancer by type II PRMT5.
引用
收藏
页码：269 / 273
页数：5
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