Arginine methyltransferase inhibitor 1 exhibits antitumor effects against cervical cancer in vitro and in vivo

被引：7
|
作者：
Dong, Shu-Hong [1 ]
Wang, Xing [2 ]
Tian, San-Chun [1 ]
Ma, Neng-Qian [2 ]
Zhang, Xin-Yang [2 ]
Liu, Yapeng [1 ]
Zhang, Bao-Lai [1 ]
Wu, Yong-Jie [1 ]
机构：
[1] Lanzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Lanzhou, Gansu, Peoples R China
[2] Lanzhou Univ, Sch Med, Hosp 2, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou, Gansu, Peoples R China
来源：
PHARMAZIE | 2018年 / 73卷 / 05期
关键词：
CELL LUNG-CANCER; TUMOR-SUPPRESSOR; PROTEIN; METHYLATION; PRMT5; GROWTH; EIF4E; LYMPHOMA;
D O I：
10.1691/ph.2018.8365
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Protein arginine methyltransferase 5 (PRMT5), a type II PRMT, is highly expressed in several types of tumors including cervical cancer. Arginine methyltransferase inhibitor 1 (AMI-1) inhibits solid tumors by targeting PRMT5. However, the effect of AMI-1 on cervical cancer is still unknown. In this study, we provided the first evidence that AMI-1 reduced cervical cancer cell proliferation, colony formation and promoted cell apoptosis in vitro. Suppression of tumorigenicity was also confirmed in vivo. Mechanistic studies revealed that AMI-1 significantly reduced PRMT5 level in cells and mice xenografts model of cervical cancer. These results suggest that AMI-1 inhibits cervical cancer by type II PRMT5.
引用
收藏
页码：269 / 273
页数：5
相关论文
共 50 条
  • [1] GuiErBai: a potent inhibitor, exhibiting broadly antitumor effect against cervical cancer in vitro and in vivo
    Qin, Hong-en
    Peng, Lei
    Xu, Yuan-cui
    Zhang, Zi-xiong
    Tian, Ren-fu
    Wan, Zhong-xian
    Pu, Dao-jing
    Li, Hong-chun
    Wu, Fei
    Zheng, Liangdong
    Xu, Xian-shun
    [J]. FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [2] Arginine methyltransferase inhibitor-1 inhibits sarcoma viability in vitro and in vivo
    Zhang, Baolai
    Chen, Xue
    Ge, Suyin
    Peng, Caili
    Zhang, Su
    Chen, Xu
    Liu, Tao
    Zhang, Wenkai
    [J]. ONCOLOGY LETTERS, 2018, 16 (02) : 2161 - 2166
  • [3] CUDC-907 exhibits potent antitumor effects against ovarian cancer through multiple in vivo and in vitro mechanisms
    Wang, Yuanpei
    Wen, Jing
    Sun, Xiangyi
    Sun, Yi
    Liu, Yuchen
    Cheng, Xiaoran
    Wu, Weijia
    Liu, Qianwen
    Ren, Fang
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2024, 93 (04) : 295 - 306
  • [4] CUDC-907 exhibits potent antitumor effects against ovarian cancer through multiple in vivo and in vitro mechanisms
    Yuanpei Wang
    Jing Wen
    Xiangyi Sun
    Yi Sun
    Yuchen Liu
    Xiaoran Cheng
    Weijia Wu
    Qianwen Liu
    Fang Ren
    [J]. Cancer Chemotherapy and Pharmacology, 2024, 93 : 295 - 306
  • [5] SY-1365, a selective CDK7 inhibitor, exhibits potent antitumor activity against ovarian cancer models in vitro and in vivo
    Konstantinopoulos, Panagiotis A.
    Hodgson, Graeme
    Rajagopal, Nisha
    Johannessen, Liv
    Liu, Joyce F.
    Kirschmeier, Paul T.
    Zhou, Shan
    Cam Anh Tran
    Orlando, David
    Fritz, Christian
    di Tomaso, Emmanuelle
    Matulonis, Ursula A.
    [J]. CANCER RESEARCH, 2018, 78 (13)
  • [6] Small molecule inhibitor of Stat3 induces antitumor cell effects in vitro and antitumor effects in vivo against human glioma or breast cancer model
    Yue, Peibin
    Lopez-Tapia, Francisco
    Tius, Marcus
    Turkson, James
    [J]. CANCER RESEARCH, 2014, 74 (19)
  • [7] Acetylsalicylic Acid Exhibits Antitumor Effects in Esophageal Adenocarcinoma Cells In Vitro and In Vivo
    Piazuelo, Elena
    Esquivias, Paula
    De Martino, Alba
    Cebrian, Carmelo
    Conde, Blanca
    Santander, Sonia
    Emperador, Sonia
    Asuncion Garcia-Gonzalez, Maria
    Carrera-Lasfuentes, Patricia
    Lanas, Angel
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2016, 61 (10) : 2896 - 2907
  • [8] Acetylsalicylic Acid Exhibits Antitumor Effects in Esophageal Adenocarcinoma Cells In Vitro and In Vivo
    Elena Piazuelo
    Paula Esquivias
    Alba De Martino
    Carmelo Cebrián
    Blanca Conde
    Sonia Santander
    Sonia Emperador
    María Asunción García-González
    Patricia Carrera-Lasfuentes
    Angel Lanas
    [J]. Digestive Diseases and Sciences, 2016, 61 : 2896 - 2907
  • [9] Antitumor effects of etodolac, a selective cyclooxygenase-II inhibitor, against human prostate cancer cell lines in vitro and in vivo
    Shigemura, K
    Shirakawa, T
    Wada, Y
    Kamidono, S
    Fujisawa, M
    Gotoh, A
    [J]. UROLOGY, 2005, 66 (06) : 1239 - 1244
  • [10] Antitumor Efficacy of α-Solanine against Pancreatic Cancer In Vitro and In Vivo
    Lv, Chongqing
    Kong, Hongru
    Dong, Guohua
    Liu, Lewei
    Tong, Kun
    Sun, Hongwei
    Chen, Bicheng
    Zhang, Chunwu
    Zhou, Mengtao
    [J]. PLOS ONE, 2014, 9 (02):
12345