A stereoselective approach to the angucyclinone antibiotics: A total synthesis of (±)-urdamycinone B

被引：3
|
作者：
Osman, Hasnah [1 ]
Larsen, David S. [2 ]
Muralikrishna, Akkarapalli [1 ]
机构：
[1] Univ Sains Malaysia, Sch Chem Sci, Gelugor 11800, Penang, Malaysia
[2] Univ Otago, Dept Chem, POB 56, Dunedin, New Zealand
来源：
ARABIAN JOURNAL OF CHEMISTRY | 2019年 / 12卷 / 08期
关键词：
Urdamycinone B; Total synthesis; Stereoselectivity; Angucyclinone antibiotics; DIELS-ALDER APPROACH; URDAMYCINONE-B;
D O I：
10.1016/j.arabjc.2015.04.022
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A stereoselective chiral Lewis acid promoted reaction of siloxydiene (+/-)-13 and dienophile complex 18, gave a 4:1 mixture of urdamycinone B (1) and its C-3 epimer (24) in several steps in 12% overall yield. Separation of these products was achieved by high performance liquid chromatography (HPLC). (C) 2015 Published by Elsevier B.V. on behalf of King Saud University.
引用
收藏
页码：2501 / 2512
页数：12
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