A stereoselective approach to the angucyclinone antibiotics: A total synthesis of (±)-urdamycinone B

被引：3

作者：

Osman, Hasnah ^{[1
]}

Larsen, David S. ^{[2
]}

Muralikrishna, Akkarapalli ^{[1
]}

机构：

[1] Univ Sains Malaysia, Sch Chem Sci, Gelugor 11800, Penang, Malaysia

[2] Univ Otago, Dept Chem, POB 56, Dunedin, New Zealand

来源：

ARABIAN JOURNAL OF CHEMISTRY | 2019年 / 12卷 / 08期

关键词：

Urdamycinone B; Total synthesis; Stereoselectivity; Angucyclinone antibiotics; DIELS-ALDER APPROACH; URDAMYCINONE-B;

D O I：

10.1016/j.arabjc.2015.04.022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A stereoselective chiral Lewis acid promoted reaction of siloxydiene (+/-)-13 and dienophile complex 18, gave a 4:1 mixture of urdamycinone B (1) and its C-3 epimer (24) in several steps in 12% overall yield. Separation of these products was achieved by high performance liquid chromatography (HPLC). (C) 2015 Published by Elsevier B.V. on behalf of King Saud University.

引用

页码：2501 / 2512

页数：12

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