Patients with dystrophinopathy show evidence of increased oxidative stress

被引：90
|
作者：
Rodriguez, MC
Tarnopolsky, MA
机构：
[1] McMaster Univ, Ctr Med, Neuromusc Dis Unit, Hamilton, ON L8N 3Z5, Canada
[2] McMaster Univ, Dept Kinesiol, Hamilton, ON L8N 3Z5, Canada
[3] McMaster Univ, Dept Med Neurol & Rehab, Hamilton, ON L8N 3Z5, Canada
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2003年 / 34卷 / 09期
关键词：
muscular dystrophy; free radicals; DNA damage; 8-hydroxy-2 '-deoxyguanosine;
D O I：
10.1016/S0891-5849(03)00141-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Duchenne muscular dystrophy (DMD) is associated with an increase in oxidative stress. We measured 24 h 8-hydroxy-2'-deoxyguanosine (8-OHdG) excretion in 24 patients with MD (DMD + Becker's MD), 23 with myotonic dystrophy, and 34 healthy controls. The 8-OHdG/creatinine ratio was higher in patients with dystrophinopathy (up arrow 48%, p < .01) but not myotonic dystrophy, as compared to healthy controls. These results indicate that 8-OHdG excretion can be used as a marker of oxidative stress in clinical trials with dystrophinopathy. (C) 2003 Elsevier Inc.
引用
收藏
页码：1217 / 1220
页数：4
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