Patients with dystrophinopathy show evidence of increased oxidative stress

被引：90
|
作者：
Rodriguez, MC
Tarnopolsky, MA
机构：
[1] McMaster Univ, Ctr Med, Neuromusc Dis Unit, Hamilton, ON L8N 3Z5, Canada
[2] McMaster Univ, Dept Kinesiol, Hamilton, ON L8N 3Z5, Canada
[3] McMaster Univ, Dept Med Neurol & Rehab, Hamilton, ON L8N 3Z5, Canada
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2003年 / 34卷 / 09期
关键词：
muscular dystrophy; free radicals; DNA damage; 8-hydroxy-2 '-deoxyguanosine;
D O I：
10.1016/S0891-5849(03)00141-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Duchenne muscular dystrophy (DMD) is associated with an increase in oxidative stress. We measured 24 h 8-hydroxy-2'-deoxyguanosine (8-OHdG) excretion in 24 patients with MD (DMD + Becker's MD), 23 with myotonic dystrophy, and 34 healthy controls. The 8-OHdG/creatinine ratio was higher in patients with dystrophinopathy (up arrow 48%, p < .01) but not myotonic dystrophy, as compared to healthy controls. These results indicate that 8-OHdG excretion can be used as a marker of oxidative stress in clinical trials with dystrophinopathy. (C) 2003 Elsevier Inc.
引用
收藏
页码：1217 / 1220
页数：4
相关论文
共 50 条
  • [21] Increased oxidative stress in patients undergoing hemodialysis
    Müller, C
    Gradinger, M
    Rath, T
    Albert, FW
    Vienken, J
    Eisenbrand, G
    Janzowski, C
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2002, 365 : R152 - R152
  • [22] Increased oxidative stress in patients with hydatidiform mole
    Harma, M
    Harma, M
    Erel, O
    SWISS MEDICAL WEEKLY, 2003, 133 (41-42) : 563 - 566
  • [23] Increased systemic oxidative stress in patients with keratoconus
    Toprak, I.
    Kucukatay, V.
    Yildirim, C.
    Kilic-Toprak, E.
    Kilic-Erkek, O.
    EYE, 2014, 28 (03) : 285 - 289
  • [24] Increased Oxidative Stress in Patients with Pseudoexfoliation Syndrome
    Cumurcu, Tongabay
    Gunduz, Abuzer
    Ozyurt, Huseyin
    Nurcin, Hatun
    Atis, Omer
    Egri, Mucahit
    OPHTHALMIC RESEARCH, 2010, 43 (04) : 169 - 172
  • [25] Increased systemic oxidative stress in patients with keratoconus
    I Toprak
    V Kucukatay
    C Yildirim
    E Kilic-Toprak
    O Kilic-Erkek
    Eye, 2014, 28 : 285 - 289
  • [26] Oxidative stress markers are increased in patients with mastocytosis
    Gangemi, S.
    Minciullo, P. L.
    Magliacane, D.
    Saitta, S.
    Loffredo, S.
    Saija, A.
    Cristani, M.
    Marone, G.
    Triggiani, M.
    ALLERGY, 2015, 70 (04) : 436 - 442
  • [27] Increased oxidative stress in patients with essential thrombocythemia
    Durmus, A.
    Mentese, A.
    Yilmaz, M.
    Sumer, A.
    Akalin, I.
    Topal, C.
    Alver, A.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2013, 17 (21) : 2860 - 2866
  • [28] Evidence of Increased Oxidative Stress in Aged Mesenteric Lymphatic Vessels
    Thangaswamy, Sangeetha
    Bridenbaugh, Eric A.
    Gashev, Anatoliy A.
    LYMPHATIC RESEARCH AND BIOLOGY, 2012, 10 (02) : 53 - 62
  • [29] Antioxidant Systems in Obese Hypertensive Patients. Evidence for Increased Oxidative Stress: Preliminary Results
    Mancini, A.
    Mettimano, M.
    Leone, E.
    Di Donna, V.
    Scagliusi, A.
    Viviani, D.
    Savi, L.
    Pontecorvi, A.
    Silvestrini, A.
    Meucci, E.
    PROCEEDINGS OF THE 13TH INTERNATIONAL CONGRESS OF ENDOCRINOLOGY, 2008, : 379 - +
  • [30] Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress
    Terman, A
    Abrahamsson, N
    Brunk, UT
    EXPERIMENTAL GERONTOLOGY, 1999, 34 (06) : 755 - 770
12345