Catalyst-Free and One-Pot Procedure for Fast Formation of α-Ketoamides Using α-Oxocarboxylic Acids and Amines at Room Temperature

被引：8

作者：

Liu, Fuyan ^{[1
,2
]}

Liu, Yaxu ^{[1
,2
]}

Chen, Yiping ^{[1
,2
]}

Sun, Zhongliang ^{[1
,2
]}

Wang, Bo ^{[1
,2
]}

机构：

[1] Hainan Univ, Minist Educ, Key Lab Adv Mat Trop Isl Resources, 58 Renmin AVE, Haikou 570228, Peoples R China

[2] Hainan Univ, State Key Lab Marine Resource Utilisat South Chin, 58 Renmin AVE, Haikou 570228, Peoples R China

来源：

CHEMISTRYSELECT | 2017年 / 2卷 / 17期

基金：

美国国家科学基金会;

关键词：

catalyst-free; alpha-ketoamide; one-pot; OXIDATIVE AMIDATION; METHYL KETONES; TERTIARY ENAMIDES; TERMINAL ALKENES; HIGHLY EFFICIENT; DERIVATIVES; AMIDES; ETHYLARENES; GENERATION; AMINATION;

D O I：

10.1002/slct.201700923

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient, one-pot, and catalyst-free approach for fast synthesis of an array of alpha-ketoamides starting from easily obtainable alpha-oxocarboxylic acids and primary-/secondary-amines has been developed via insitu activation of acids using stoichiometric 2,4,6-trichloro-1,3,5-trizaine at room temperature, reactions could proceed smoothly to provide the corresponding alpha-ketoamides in good to excellent yields of up to 99%.

引用

页码：4638 / 4641

页数：4

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