Sex and Gender Differences in Clinical Pharmacology: Implications for Transgender Medicine

被引：28
|
作者：
Cirrincione, Lauren R. [1 ]
Huang, Kai J. [2 ]
机构：
[1] Univ Washington, Dept Pharm, Seattle, WA 98195 USA
[2] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2021年 / 110卷 / 04期
关键词：
BONE-MINERAL DENSITY; TO-FEMALE TRANSSEXUALS; HORMONE REPLACEMENT THERAPY; PLASMA TOTAL HOMOCYSTEINE; MENSTRUAL-CYCLE PHASE; ORAL-CONTRACEPTIVES; INTRAINDIVIDUAL VARIABILITY; ENDOCRINE TREATMENT; CYP2C19; ACTIVITY; BODY-COMPOSITION;
D O I：
10.1002/cpt.2234
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The transgender adult population is growing globally, but clinical pharmacology has lagged behind other areas of transgender medicine. Medical care for transgender adults may include long-term testosterone or estrogen treatment to align secondary sex characteristics with gender identity. Clinicians often use drug-drug interaction data from the general adult population to predict medication disposition or safety among transgender adults. However, this approach does not address the complex pharmacodynamic effects of hormone therapy in transgender adults. In this review, we critically examine sex-related and gender-related differences in clinical pharmacology and apply these data to discuss current gaps in transgender medicine.
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页码：897 / 908
页数：12
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