Preparation and Molecular Composition of an Inclusion Complex of Dilsulfiram and Hydroxypropyl-β-Cyclodextrin

被引：1

作者：

Tyukova, V. S. ^{[1
,2
]}

Kedik, S. A. ^{[1
,2
]}

Panov, A. V. ^{[1
,2
]}

Zhavoronok, E. S. ^{[1
,2
]}

Zolotareva, M. S. ^{[1
]}

机构：

[1] MV Lomonosov Moscow Technol Univ, 78 Vernadskii Prospekt, Moscow 119571, Russia

[2] Inst Pharmaceut Technol, 21-32 Skolkovskoe Highway, Moscow 121353, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 50卷 / 01期

关键词：

hydroxypropyl-beta-cyclodextrin; disulfiram; inclusion complex; ratio of components; EYE DROPS; ICR/F RATS; DISULFIRAM; DIETHYLDITHIOCARBAMATE; PEROXIDE; LENS;

D O I：

10.1007/s11094-016-1395-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An original method is proposed for preparing an inclusion complex based on disulfiram with hydroxypropyl-beta-cyclodextrin for the treatment of cataract. Preparation of soluble product required a molar ratio of hydroxypropyl-beta-cyclodextrin to disulfiram of at least 2:1, while the molar ratio of components in the inclusion complex was 1:1. Gel permeation chromatography was used to measure the mean hydrodynamic diameter of hydroxypropyl-beta-cyclodextrin and inclusion complex molecules, and their molecular weights were calculated - which in both cases were 1.0 kDa. A scheme for the equilibrium of the inclusion complex is proposed.

引用

页码：38 / 43

页数：6

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