Preparation and Molecular Composition of an Inclusion Complex of Dilsulfiram and Hydroxypropyl-β-Cyclodextrin

被引：1
|
作者：
Tyukova, V. S. [1 ,2 ]
Kedik, S. A. [1 ,2 ]
Panov, A. V. [1 ,2 ]
Zhavoronok, E. S. [1 ,2 ]
Zolotareva, M. S. [1 ]
机构：
[1] MV Lomonosov Moscow Technol Univ, 78 Vernadskii Prospekt, Moscow 119571, Russia
[2] Inst Pharmaceut Technol, 21-32 Skolkovskoe Highway, Moscow 121353, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 50卷 / 01期
关键词：
hydroxypropyl-beta-cyclodextrin; disulfiram; inclusion complex; ratio of components; EYE DROPS; ICR/F RATS; DISULFIRAM; DIETHYLDITHIOCARBAMATE; PEROXIDE; LENS;
D O I：
10.1007/s11094-016-1395-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An original method is proposed for preparing an inclusion complex based on disulfiram with hydroxypropyl-beta-cyclodextrin for the treatment of cataract. Preparation of soluble product required a molar ratio of hydroxypropyl-beta-cyclodextrin to disulfiram of at least 2:1, while the molar ratio of components in the inclusion complex was 1:1. Gel permeation chromatography was used to measure the mean hydrodynamic diameter of hydroxypropyl-beta-cyclodextrin and inclusion complex molecules, and their molecular weights were calculated - which in both cases were 1.0 kDa. A scheme for the equilibrium of the inclusion complex is proposed.
引用
收藏
页码：38 / 43
页数：6
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