Preparation and Molecular Composition of an Inclusion Complex of Dilsulfiram and Hydroxypropyl-β-Cyclodextrin

被引：1
|
作者：
Tyukova, V. S. [1 ,2 ]
Kedik, S. A. [1 ,2 ]
Panov, A. V. [1 ,2 ]
Zhavoronok, E. S. [1 ,2 ]
Zolotareva, M. S. [1 ]
机构：
[1] MV Lomonosov Moscow Technol Univ, 78 Vernadskii Prospekt, Moscow 119571, Russia
[2] Inst Pharmaceut Technol, 21-32 Skolkovskoe Highway, Moscow 121353, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 50卷 / 01期
关键词：
hydroxypropyl-beta-cyclodextrin; disulfiram; inclusion complex; ratio of components; EYE DROPS; ICR/F RATS; DISULFIRAM; DIETHYLDITHIOCARBAMATE; PEROXIDE; LENS;
D O I：
10.1007/s11094-016-1395-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An original method is proposed for preparing an inclusion complex based on disulfiram with hydroxypropyl-beta-cyclodextrin for the treatment of cataract. Preparation of soluble product required a molar ratio of hydroxypropyl-beta-cyclodextrin to disulfiram of at least 2:1, while the molar ratio of components in the inclusion complex was 1:1. Gel permeation chromatography was used to measure the mean hydrodynamic diameter of hydroxypropyl-beta-cyclodextrin and inclusion complex molecules, and their molecular weights were calculated - which in both cases were 1.0 kDa. A scheme for the equilibrium of the inclusion complex is proposed.
引用
收藏
页码：38 / 43
页数：6
相关论文
共 50 条
  • [1] Preparation and Molecular Composition of an Inclusion Complex of Dilsulfiram and Hydroxypropyl-β-Cyclodextrin
    V. S. Tyukova
    S. A. Kedik
    A. V. Panov
    E. S. Zhavoronok
    M. S. Zolotareva
    [J]. Pharmaceutical Chemistry Journal, 2016, 50 : 38 - 43
  • [2] Preparation and characterization of the inclusion complex of furosemide with hydroxypropyl-β-cyclodextrin
    Vlachou, M
    Papaïoannou, G
    [J]. JOURNAL OF BIOMATERIALS APPLICATIONS, 2003, 17 (03) : 197 - 206
  • [3] Preparation and stability of the inclusion complex of astaxanthin with hydroxypropyl-β-cyclodextrin
    Yuan, Chao
    Jin, Zhengyu
    Xu, Xueming
    Zhuang, Haining
    Shen, Wangyang
    [J]. FOOD CHEMISTRY, 2008, 109 (02) : 264 - 268
  • [4] Preparation and characterization of the inclusion complex of hypocrellin A with hydroxypropyl-β-cyclodextrin
    Yujie Su
    Shengqi Rao
    Yujie Cai
    Yanjun Yang
    [J]. European Food Research and Technology, 2010, 231 : 781 - 788
  • [5] Preparation and characterization of the inclusion complex of hypocrellin A with hydroxypropyl-β-cyclodextrin
    Su, Yujie
    Rao, Shengqi
    Cai, Yujie
    Yang, Yanjun
    [J]. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 2010, 231 (05) : 781 - 788
  • [6] PREPARATION AND CHARACTERIZATION OF INCLUSION COMPLEXES FORMED BY AVOBENZONE WITH β-CYCLODEXTRIN, HYDROXYPROPYL-β-CYCLODEXTRIN AND HYDROXYPROPYL-α-CYCLODEXTRIN
    Sbora, Raluca
    Budura, Emma Adriana
    Nitulescu, George Mihai
    Balaci, Teodora
    Lupuleasa, Dumitru
    [J]. FARMACIA, 2015, 63 (04) : 548 - 555
  • [7] Inclusion Complex of Paclitaxel in Hydroxypropyl-β-cyclodextrin
    CHEN Yue 1
    2. Institute of Frontier Medical Science
    3. Center of Drug Discovery
    [J]. Chemical Research in Chinese Universities, 2005, (06) : 749 - 752
  • [8] Inclusion complex of carprofen with hydroxypropyl-β-cyclodextrin
    Chen, FA
    Wu, AB
    Chen, CY
    [J]. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2003, 46 (1-2) : 111 - 115
  • [9] Inclusion Complex of Carprofen with Hydroxypropyl-β-cyclodextrin
    Fu-An Chen
    An-Bang Wu
    Chau-Yang Chen
    [J]. Journal of inclusion phenomena and macrocyclic chemistry, 2003, 46 : 111 - 115
  • [10] Inclusion complex of paclitaxel in hydroxypropyl-β-cyclodextrin
    Chen, Y
    Zhou, YL
    Ren, Y
    Yan, WQ
    [J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2005, 21 (06) : 749 - 752
12345