Novel pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and 5-HT1A receptor

被引：12
|
作者：
Zhou, Dahui
Hatzenbuhler, Nicole T.
Gross, Jonathan L.
Harrison, Boyd L.
Evrard, Deborah A.
Chlenov, Michael
Golembieski, Jeannette
Hornby, Geoffrey
Schechter, Lee E.
Smith, Deborah L.
Andree, Terrance H.
Stack, Gary P.
机构：
[1] Wyeth Ayerst Res, Chem & Screening Sci, Princeton, NJ 08543 USA
[2] Wyeth Ayerst Res, Neurosci Discovery Res, Princeton, NJ 08543 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 11期
关键词：
serotonin transporter; 5-HT1A receptor;
D O I：
10.1016/j.bmcl.2007.03.049
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Structural modifications of the initial lead, 3-aminochroman (4), led to the identification of a novel series of pyridyl-fused amino chroman derivatives (5-8) and the structural isomers (9-12). The compounds described were evaluated for dual 5-HT transporter inhibitory and 5-HT1A receptor activities. The design strategy, synthesis, and in vitro biological characterization for these novel compounds are described. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3117 / 3121
页数：5
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