Novel pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and 5-HT1A receptor

被引：12

作者：

Zhou, Dahui

Hatzenbuhler, Nicole T.

Gross, Jonathan L.

Harrison, Boyd L.

Evrard, Deborah A.

Chlenov, Michael

Golembieski, Jeannette

Hornby, Geoffrey

Schechter, Lee E.

Smith, Deborah L.

Andree, Terrance H.

Stack, Gary P.

机构：

[1] Wyeth Ayerst Res, Chem & Screening Sci, Princeton, NJ 08543 USA

[2] Wyeth Ayerst Res, Neurosci Discovery Res, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 11期

关键词：

serotonin transporter; 5-HT1A receptor;

D O I：

10.1016/j.bmcl.2007.03.049

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structural modifications of the initial lead, 3-aminochroman (4), led to the identification of a novel series of pyridyl-fused amino chroman derivatives (5-8) and the structural isomers (9-12). The compounds described were evaluated for dual 5-HT transporter inhibitory and 5-HT1A receptor activities. The design strategy, synthesis, and in vitro biological characterization for these novel compounds are described. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3117 / 3121

页数：5

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