Novel pyridyl-fused 3-amino chroman derivatives with dual action at serotonin transporter and 5-HT1A receptor

被引：12
|
作者：
Zhou, Dahui
Hatzenbuhler, Nicole T.
Gross, Jonathan L.
Harrison, Boyd L.
Evrard, Deborah A.
Chlenov, Michael
Golembieski, Jeannette
Hornby, Geoffrey
Schechter, Lee E.
Smith, Deborah L.
Andree, Terrance H.
Stack, Gary P.
机构：
[1] Wyeth Ayerst Res, Chem & Screening Sci, Princeton, NJ 08543 USA
[2] Wyeth Ayerst Res, Neurosci Discovery Res, Princeton, NJ 08543 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 11期
关键词：
serotonin transporter; 5-HT1A receptor;
D O I：
10.1016/j.bmcl.2007.03.049
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Structural modifications of the initial lead, 3-aminochroman (4), led to the identification of a novel series of pyridyl-fused amino chroman derivatives (5-8) and the structural isomers (9-12). The compounds described were evaluated for dual 5-HT transporter inhibitory and 5-HT1A receptor activities. The design strategy, synthesis, and in vitro biological characterization for these novel compounds are described. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3117 / 3121
页数：5
相关论文
共 50 条
  • [1] Synthesis and SAR evaluation of lactam-fused chroman derivatives having dual affinity at serotonin 5-HT1A receptor and serotonin transporter
    Shen, Zhongqi
    Hatzenbuhler, Nicole T.
    Evrard, Deborah A.
    Chlenov, Michael
    Harrison, Boyd L.
    Magolda, Ronald L.
    Abou-Gharbia, Magid
    Hornby, Geoffrey
    Smith, Deborah L.
    Sullivan, Kelly M.
    Schechter, Lee E.
    Andree, Terrance H.
    Ramamoorthy, P. Siva
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 768 - 768
  • [2] Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity
    Venkatesan, Aranapakam M.
    Dos Santos, O.
    Ellingboe, John
    Evrard, Deborah A.
    Harrison, Boyd L.
    Smith, Deborah L.
    Scerni, Rosemary
    Hornby, Geoffrey A.
    Schechter, Lee E.
    Andree, Terrence H.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (03) : 824 - 827
  • [3] Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT1A receptor and the serotonin transporter
    Shen, Zhongqi
    Ramamoorthy, P. Siva
    Hatzenbuhler, Nicole T.
    Evrard, Deborah A.
    Childers, Wayne
    Harrison, Boyd L.
    Chlenov, Michael
    Hornby, Geoffrey
    Smith, Deborah L.
    Sullivan, Kelly M.
    Schechter, Lee E.
    Andree, Terrance H.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (01) : 222 - 227
  • [4] MEDI 274-Synthesis and SAR evaluation of lactam-fused chroman derivatives having dual affinity at serotonin 5-HT1A receptor and serotonin transporter
    Patrone, James
    Dotson, Garry D.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 884 - 884
  • [5] Novel Mannich Bases, 5-Arylimidazolidine-2,4-dione Derivatives with Dual 5-HT1A Receptor and Serotonin Transporter Affinity
    Czopek, Anna
    Kolaczkowski, Marcin
    Bucki, Adam
    Byrtus, Hanna
    Pawlowski, Maciej
    Siwek, Agata
    Bojarski, Andrzej J.
    Bednarski, Marek
    Wrobel, Dagmara
    Wesolowska, Anna
    ARCHIV DER PHARMAZIE, 2013, 346 (02) : 98 - 109
  • [6] Synthesis and biological evaluation of novel compounds within a class of 3-aminochroman derivatives with dual 5-HT1A receptor and serotonin transporter affinity
    Hatzenbuhler, Nicole T.
    Evrard, Deborah A.
    Harrison, Boyd L.
    Huryn, Donna
    Inghrim, Jennifer
    Kraml, Christina
    Mattes, James F.
    Mewshaw, Richard E.
    Zhou, Dahui
    Hornby, Geoffrey
    Lin, Qian
    Smith, Deborah L.
    Sullivan, Kelly M.
    Schechter, Lee E.
    Beyer, Chad E.
    Andree, Terrance H.
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (15) : 4785 - 4789
  • [7] Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands
    Walory, Jaroslaw
    Mielczarek, Lidia
    Jaronczyk, Malgorzata
    Koronkiewicz, Miroslawa
    Kossakowski, Jerzy
    Bugno, Ryszard
    Bojarski, Andrzej J.
    Chilmonczyk, Zdzislaw
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (10)
  • [8] Dual actions of 5-MeO-DIPT at the serotonin transporter and serotonin 5-HT1A receptor in the mouse striatum and prefrontal cortex
    Hagino, Yoko
    Hall, Frank Scott
    Uhl, George R.
    Sora, Ichiro
    Ikeda, Kazutaka
    NEUROPSYCHOPHARMACOLOGY REPORTS, 2021, 41 (01) : 91 - 101
  • [9] New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants
    Martínez-Esparza, J
    Oficialdegui, AM
    Pérez-Silanes, S
    Heras, B
    Orús, L
    Palop, JA
    Lasheras, B
    Roca, J
    Mourelle, H
    Bosch, A
    Del Castillo, JC
    Tordera, R
    Del Río, J
    Monge, A
    JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (03) : 418 - 428
  • [10] Novel Selective Arylpiperazine Ligands for the Serotonin 5-HT1a Receptor
    Romeo, G.
    JOINT MEETING ON MEDICAL CHEMISTRY, 2009, : 15 - 19
12345