Synthesis and antimicrobial activity of 2,10-dichloro-6-substituted amino acid ester-12H-dibenzo[d,g][1,3,2]dioxaphosphocin-6-oxides

被引：0
|
作者：
Kumar, B. S. [2 ]
Reddy, M. V. N. [1 ]
Reddy, G. C. S. [1 ]
Krishna, A. B. [1 ]
Reddy, C. S. [1 ]
机构：
[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India
[2] Shizuoka Univ, Dept Nanomat, Grad Sch Sci & Technol, Hamamatsu, Shizuoka 4328561, Japan
来源：
BULGARIAN CHEMICAL COMMUNICATIONS | 2009年 / 41卷 / 04期
关键词：
Dioxaphosphocin-6-oxides; amino acid esters; spectral studies; antimicrobial activity; HUMAN-IMMUNODEFICIENCY-VIRUS; ANTI-HIV EFFICACY; PHOSPHORAMIDATE DERIVATIVES; D4T; INHIBITORS; INVITRO;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new class of 2,10-dichloro-6-substituted amino acid ester-12H-dibenzo[d,g][1,3,2]dioxaphosphocin-6-oxides have been synthesized in good yields via the condensation of 2,10-dichloro-6-chloro-12H-dibenzo[d,g][1,3,2]dioxaphosphocin with various amino acid esters in the presence of triethylamine. The title compounds were characterized by elemental analysis, IRS, NMR (H-1, C-13 and P-31) and mass spectral studies and found to exhibit moderate antimicrobial activity.
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页码：422 / 426
页数：5
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