Synthesis and antimicrobial activity of 2,10-dichloro-6-substituted amino acid ester-12H-dibenzo[d,g][1,3,2]dioxaphosphocin-6-oxides

被引：0

作者：

Kumar, B. S. ^{[2
]}

Reddy, M. V. N. ^{[1
]}

Reddy, G. C. S. ^{[1
]}

Krishna, A. B. ^{[1
]}

Reddy, C. S. ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

[2] Shizuoka Univ, Dept Nanomat, Grad Sch Sci & Technol, Hamamatsu, Shizuoka 4328561, Japan

来源：

BULGARIAN CHEMICAL COMMUNICATIONS | 2009年 / 41卷 / 04期

关键词：

Dioxaphosphocin-6-oxides; amino acid esters; spectral studies; antimicrobial activity; HUMAN-IMMUNODEFICIENCY-VIRUS; ANTI-HIV EFFICACY; PHOSPHORAMIDATE DERIVATIVES; D4T; INHIBITORS; INVITRO;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new class of 2,10-dichloro-6-substituted amino acid ester-12H-dibenzo[d,g][1,3,2]dioxaphosphocin-6-oxides have been synthesized in good yields via the condensation of 2,10-dichloro-6-chloro-12H-dibenzo[d,g][1,3,2]dioxaphosphocin with various amino acid esters in the presence of triethylamine. The title compounds were characterized by elemental analysis, IRS, NMR (H-1, C-13 and P-31) and mass spectral studies and found to exhibit moderate antimicrobial activity.

引用

页码：422 / 426

页数：5

共 50 条

[11] Solvent-free synthesis of novel 2,10-dichoro-12-trichloromethyl-6-substituted xanthato-12H-dibenzo[d,g] [1,3,2] dioxaphosphocin-6-sulfides
Reddy, M. Veera Narayana
Reddy, G. Chandra Sekhar
Sundar, Ch Syama
Kumar, K. Suresh
Kumar, K. Ananda
Reddy, C. Suresh
GREEN CHEMISTRY LETTERS AND REVIEWS, 2012, 5 (03) : 475 - 479
[12] Synthesis and spectral characteristics of 6-O/S-alkoxyethyl-12H-[1,3,2]dioxaphosphocin-6-oxides/sulfides
Zhang, Xiao-Mei
Wang, Dao-Quan
Chen, Wan-Yi
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2007, 27 (05) : 623 - 628
[13] 2,10-DICHLORO-6-(SUBSTITUTED ARYLOXY)DIBENZO[D,G][1,3,6,2]DIOXATHIAPHOSPHOCIN 6-OXIDES - SYNTHESIS AND SPECTRAL CHARACTERISTICS
REDDY, CD
ANURADHA, K
BERLIN, KD
SUNTHANKAR, PS
MULEKAR, SV
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1990, 22 (02) : 229 - 233
[14] Synthesis of 6-aryloxy- and 6-p-tolylthioxy-2,10-dichloro-12-trichloromethyl-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxides - X-ray diffraction analyses of 6-(4'-chlorophenoxy)-2,10-dichloro-12-trichloromethyl-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxide and triethylammonium 2-methylphenyl 2-[{2',2',2'-trichloro-1'-(2''-hydroxyl-5''-chlorophenyl)}ethyl]-4-chlorophenyl phosphate
Reddy, CD
Reddy, BS
Reddy, PM
Berlin, KD
Couch, KM
Tyagi, S
Hossain, MB
VanderHelm, D
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1996, 115 : 149 - 160
[15] SYNTHESIS AND SPECTRAL-ANALYSIS OF 6-SUBSTITUTED-1,2,4,8,10,11-HEXACHLORO-12H-DIBENZO[D,G][1,3,2]DIOXAPHOSPHOCIN 6-OXIDES
REDDY, BS
REDDY, CD
REDDY, PM
HETEROATOM CHEMISTRY, 1994, 5 (5-6) : 507 - 511
[16] STRUCTURE & CONFORMATION OF 2,10-DICHLORO DIBENZO[D,G] [1,3,6,2] DIOXATHIA AND [1,3,2] DIOXA-PHOSPHOCIN-6-OXIDES.
Krishnaiah, M.
Kumar, N. Jagadeesh
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 1999, 55 : 379 - 379
[17] STRUCTURES OF TWO 6-SUBSTITUTED [(I) CYCLO HEXYL & (II) 4-CHLOROPHENOXY] 2,10-DICHLORO-12H-DIBENZO [d,g] [1,3,2] DIOXAPHOSPHOCIN 6-OXIDES-CONFORMATION OF 8MEMBERED HETEROCYCLIC RING
Krishnaiah, Ni.
Reddy, C. Devendranath
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 1996, 52 : C272 - C272
[18] Synthesis and antimicrobial activity of 2,10-dibromo dibenzo [d,g] [1,3,6,2] dioxathiaphosphocin 6-sulfido-6-amino acid esters
Haranath, P
Anasuyamma, U
Prasad, GS
Raju, CN
Reddy, CS
HETEROCYCLIC COMMUNICATIONS, 2004, 10 (06) : 457 - 464
[19] Synthesis and chemistry of 2,4,6,8,10-pentachloro-12H-dibenzo [d,g][1,3,2]dioxaphosphocin-6-sulfide
Yang, DB
Chen, WY
Zang, EL
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2001, 21 (09) : 685 - 689
[20] Synthesis of 6-Aryloxy- and 6-P-Tolylthioxy-2,10-Dichloro-12-Trichlo romethyl$ MIN@12H-Dibenzo[d,g]-[1,3,2]Dioxaphosphocin 6-Oxides-X-ray Diffraction Analyses of 6-(4'-Chlorophenoxy)-2,10-Dichloro-12- Trichloromethyl-12H-Dibenzo[d,g]-[1,3,2] Dioxaphosphocin 6-Oxide and Triethylammonium 2-methylphenyl 2-[{2',2',2'-Trichloro-1'-(2-Hydrox yl-5$ MIN@Chlorophenyl)}Ethyl]-4-Chlorophenyl Phosphate
Phosphorus Sulphur Silicon Relat Elem, (149):

← 1 2 3 4 5 →