Imidate as the Intact Directing Group for the Cobalt-Catalyzed C-H Allylation

被引：25

作者：

Tanaka, Ryo ^{[1
]}

Tanimoto, Iku ^{[1
]}

Kojima, Masahiro ^{[1
]}

Yoshino, Tatsuhiko ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 20期

关键词：

ACTIVATION; FUNCTIONALIZATION; ISOQUINOLINES; ACCESS; COUPLING/CYCLIZATION; 1H-INDAZOLES; QUINAZOLINES; CYCLIZATION; AMIDATION; OLEFINS;

D O I：

10.1021/acs.joc.9b01972

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cobalt-catalyzed C-H allylation reactions of NH-free benzimidate using vinylcyclopropanes or allyl carbonate are reported. The reactive and relatively unstable imidate groups remain intact during the C-H allylations to afford functionalized imidates without dealcoholizations. The thus obtained allylated imidate was subsequently converted into other heterocyclic structures through a following C-H functionalization reaction, demonstrating the synthetic utility of this method.

引用

页码：13203 / 13210

页数：8

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