Non-alcoholic fatty liver disease in non-obese individuals: Prevalence, pathogenesis and treatment

Non-alcoholic fatty liver disease (NAFLD) parallels comorbidities such as metabolic syndrome, dyslipidaemia or diabetes. Although NAFLD is very prevalent in overweight-obese individuals (i.e. body mass index >= 25 kg/m(2)), recent studies point to the presence of NAFLD in non-obese individuals, for both the Asian (< 25 kg/m(2)) and Caucasian (< 30 kg/m(2)) populations. This paper discusses the pathogenic pathways and current treatment options of NAFLD in non-obese populations. In this respect, non-obese subjects also need to undergo the medical screening for NAFLD. Across the scientific community, we aim to promote the advancement of knowledge in this emerging field. (C) 2019 Elsevier Masson SAS. All rights reserved.