Non-alcoholic fatty liver disease in non-obese individuals: Prevalence, pathogenesis and treatment

被引：30
|
作者：
Molina-Molina, Emilio [1 ]
Krawczyk, Marcin [2 ,3 ]
Stachowska, Ewa [4 ]
Lammert, Frank [2 ]
Portincasa, Piero [1 ]
机构：
[1] Univ Bari, Clin Med A Murri, Dept Biomed Sci & Human Oncol, Med Sch, Piazza Giulio Cesare 11, I-70124 Bari, Italy
[2] Saarland Univ, Saarland Univ Med Ctr, Dept Med 2, Homburg, Germany
[3] Med Univ Warsaw, Dept Gen Transplant & Liver Surg, Ctr Preclin Res, Lab Metab Liver Dis, Warsaw, Poland
[4] Pomeranian Med Univ, Dept Biochem & Human Nutr, PL-71210 Szczecin, Poland
来源：
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2019年 / 43卷 / 06期
关键词：
Body weight; Fat; Genetics; NAFLD; BODY-MASS INDEX; RISK-FACTORS; TRANSIENT ELASTOGRAPHY; STIFFNESS MEASUREMENT; LEAN PATIENTS; PNPLA3; GENE; ASSOCIATION; OBESITY; SEVERITY; NAFLD;
D O I：
10.1016/j.clinre.2019.04.005
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Non-alcoholic fatty liver disease (NAFLD) parallels comorbidities such as metabolic syndrome, dyslipidaemia or diabetes. Although NAFLD is very prevalent in overweight-obese individuals (i.e. body mass index >= 25 kg/m(2)), recent studies point to the presence of NAFLD in non-obese individuals, for both the Asian (< 25 kg/m(2)) and Caucasian (< 30 kg/m(2)) populations. This paper discusses the pathogenic pathways and current treatment options of NAFLD in non-obese populations. In this respect, non-obese subjects also need to undergo the medical screening for NAFLD. Across the scientific community, we aim to promote the advancement of knowledge in this emerging field. (C) 2019 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：638 / 645
页数：8
相关论文
共 50 条
  • [21] The frequency of non-alcoholic fatty liver disease in non-obese young medical professionals
    Aziz, Bilal
    Nazar, Tazeen
    Irfan, Muhammad
    [J]. JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION, 2021, 71 (07) : 1878 - 1881
  • [22] Pathogenesis of non-alcoholic fatty liver disease
    Dowman, J. K.
    Tomlinson, J. W.
    Newsome, P. N.
    [J]. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2010, 103 (02) : 71 - 83
  • [23] Pathogenesis of non-alcoholic fatty liver disease
    Anty, Rodolphe
    Gual, Philippe
    [J]. PRESSE MEDICALE, 2019, 48 (12): : 1468 - 1483
  • [24] Pathogenesis, diagnosis and treatment of non-alcoholic fatty liver disease
    Martin Dominguez, Veronica
    Gonzalez Casas, Rosario
    Mendoza Jimenez-Ridruejo, Jorge
    Garcia Buey, Luisa
    Moreno-Otero, Ricardo
    [J]. REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS, 2013, 105 (07) : 409 - 420
  • [25] Mass spectrometry-based untargeted metabolomics study of non-obese individuals with non-alcoholic fatty liver disease
    Demirel, Metin
    Koktasoglu, Fatmanur
    Ozkan, Esin
    Agac, Halime Dulun
    Gul, Ayse Zehra
    Sharifov, Rasul
    Sarikaya, Ufuk
    Basaranoglu, Metin
    Selek, Sahabettin
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2023, 58 (11) : 1344 - 1350
  • [26] Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations
    Preiss, David
    Sattar, Naveed
    [J]. CLINICAL SCIENCE, 2008, 115 (5-6) : 141 - 150
  • [27] The significance of differences in fatty acid metabolism between obese and non-obese patients with non-alcoholic fatty liver disease
    Nakamuta, Makoto
    Kohjima, Motoyuki
    Higuchi, Nobito
    Kato, Masaki
    Kotoh, Kazuhiro
    Yoshimoto, Tsuyoshi
    Yada, Masayoshi
    Yada, Ryoko
    Takemoto, Ryosuke
    Fukuizumi, Kunitaka
    Harada, Naohiko
    Taketomi, Akinobu
    Maehara, Yoshihiko
    Nakashima, Manabu
    Enjoji, Munechika
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2008, 22 (05) : 663 - 667
  • [28] Prevalence and Risk Factors of Non-Alcoholic Fatty Liver Disease (NAFLD) in Non-Obese Patients with Schizophrenia: A Retrospective Study
    Yi, Wenying
    Wu, Haibo
    Fu, Weibin
    Feng, Huimei
    Huang, Jie
    Li, Haijing
    Song, Zhen
    Chen, Yuwei
    Zheng, Yingjun
    She, Shenglin
    [J]. DIABETES METABOLIC SYNDROME AND OBESITY, 2024, 17 : 841 - 849
  • [29] Prevalence of and risk factors for non-alcoholic fatty liver disease in a non-obese Japanese population, 2011-2012
    Nishioji, Kenichi
    Sumida, Yoshio
    Kamaguchi, Mai
    Mochizuki, Naomi
    Kobayashi, Masao
    Nishimura, Takeshi
    Yamaguchi, Kanji
    Itoh, Yoshito
    [J]. JOURNAL OF GASTROENTEROLOGY, 2015, 50 (01) : 95 - 108
  • [30] Clinical and anthropometric characteristics of non-obese non-alcoholic fatty liver disease subjects in Japan
    Shida, Takashi
    Oshida, Natsumi
    Suzuki, Hideo
    Okada, Kosuke
    Watahiki, Takahisa
    Oh, Sechang
    Kim, Taeho
    Isobe, Tomonori
    Okamoto, Yoshikazu
    Ariizumi, Shun-ichi
    Yamamoto, Masakazu
    Shoda, Junichi
    [J]. HEPATOLOGY RESEARCH, 2020, 50 (09) : 1032 - 1046
12345