In situ preparation of a highly active N-heterocyclic carbene-coordinated olefin metathesis catalyst

被引：162

作者：

Morgan, JP ^{[1
]}

Grubbs, RH ^{[1
]}

机构：

[1] CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Pasadena, CA 91125 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 20期

关键词：

D O I：

10.1021/ol0063510

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Highly active N-heterocyclic carbene-coordinated catalysts may be synthesized and used in situ, without requiring prior isolation of the catalyst. Activation of this in situ catalyst with ethereal HCl dramatically reduces the reaction times required for high conversions, A variety of alpha,beta- unsaturated carbonyl-containing substrates participate readily in cross and ring-closing metathesis reactions using this preparation.

引用

页码：3153 / 3155

页数：3

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