In situ preparation of a highly active N-heterocyclic carbene-coordinated olefin metathesis catalyst

被引:162
|
作者
Morgan, JP [1 ]
Grubbs, RH [1 ]
机构
[1] CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Pasadena, CA 91125 USA
关键词
D O I
10.1021/ol0063510
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] Highly active N-heterocyclic carbene-coordinated catalysts may be synthesized and used in situ, without requiring prior isolation of the catalyst. Activation of this in situ catalyst with ethereal HCl dramatically reduces the reaction times required for high conversions, A variety of alpha,beta- unsaturated carbonyl-containing substrates participate readily in cross and ring-closing metathesis reactions using this preparation.
引用
收藏
页码:3153 / 3155
页数:3
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