Validation of an LC-MS assay for the quantification of the enantiomers of Org 4428 in human plasma

被引：11
|
作者：
Paanakker, JE [1 ]
de Jong, J [1 ]
Thio, JMSL [1 ]
van Hal, HJM [1 ]
机构：
[1] NV Organon, Sci Dev Grp, Dept Drug Metab & Kinet, NL-5340 BH Oss, Netherlands
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 16卷 / 06期
关键词：
LC-MS; Org; 4428; enantiomers; antidepressant; human plasma; validation;
D O I：
10.1016/S0731-7085(97)00113-1
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A sensitive and selective liquid chromatographic mass spectrometric assay has been validated for the quantification of Org 4428 enantiomers in human plasma. The assay employs n-hexane extraction from alkalinized plasma, separation on a narrow-bore enantioselective normal phase Chiralpak AD column and APCI MS-MS detection. The lower limit of quantification is 0.5 ng ml(-1) plasma for the individual enantiomers. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：981 / 989
页数：9
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