Validation of an LC-MS assay for the quantification of the enantiomers of Org 4428 in human plasma

被引：11

作者：

Paanakker, JE ^{[1
]}

de Jong, J ^{[1
]}

Thio, JMSL ^{[1
]}

van Hal, HJM ^{[1
]}

机构：

[1] NV Organon, Sci Dev Grp, Dept Drug Metab & Kinet, NL-5340 BH Oss, Netherlands

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 16卷 / 06期

关键词：

LC-MS; Org; 4428; enantiomers; antidepressant; human plasma; validation;

D O I：

10.1016/S0731-7085(97)00113-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive and selective liquid chromatographic mass spectrometric assay has been validated for the quantification of Org 4428 enantiomers in human plasma. The assay employs n-hexane extraction from alkalinized plasma, separation on a narrow-bore enantioselective normal phase Chiralpak AD column and APCI MS-MS detection. The lower limit of quantification is 0.5 ng ml(-1) plasma for the individual enantiomers. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：981 / 989

页数：9

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